TY - JOUR
T1 - Human leukocyte antigen class i and II alleles and overall survival in diffuse large B-cell lymphoma and follicular lymphoma
AU - Lu, Yani
AU - Abdou, Amr M.
AU - Cerhan, James R.
AU - Morton, Lindsay M.
AU - Severson, Richard K.
AU - Davis, Scott
AU - Cozen, Wendy
AU - Rothman, Nathaniel
AU - Bernstein, Leslie
AU - Chanock, Stephen
AU - Hartge, Patricia
AU - Wang, Sophia S.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 8.1 (HLA A(*)01-B(*)08-DRB1(*)03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31 (52 of 166) DLBCL and 28 (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw(*)07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR]=1.76, 95 confidence interval [CI]=1.01-3.05); HLA-A(*)01:01 was associated with poorer OS (HR=2.23, 95 CI=1.24-4.01), and HLA-DRB1(*)13 (HR=0.12, 95 CI=0.02-0.90) and HLA-B Bw4 (HR=0.36, 95 CI=0.20-0.63) with better OS among FL patients. These results support a role for HLA in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation.
AB - Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 8.1 (HLA A(*)01-B(*)08-DRB1(*)03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31 (52 of 166) DLBCL and 28 (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw(*)07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR]=1.76, 95 confidence interval [CI]=1.01-3.05); HLA-A(*)01:01 was associated with poorer OS (HR=2.23, 95 CI=1.24-4.01), and HLA-DRB1(*)13 (HR=0.12, 95 CI=0.02-0.90) and HLA-B Bw4 (HR=0.36, 95 CI=0.20-0.63) with better OS among FL patients. These results support a role for HLA in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation.
KW - diffuse large B-cell lymphoma
KW - follicular lymphoma
KW - human leukocyte antigen
KW - survival
KW - tumor necrosis factor
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UR - http://www.scopus.com/inward/citedby.url?scp=81455132749&partnerID=8YFLogxK
U2 - 10.1100/2011/373876
DO - 10.1100/2011/373876
M3 - Article
C2 - 22125456
AN - SCOPUS:81455132749
SN - 2356-6140
VL - 11
SP - 2062
EP - 2070
JO - TheScientificWorldJournal
JF - TheScientificWorldJournal
ER -