Human leukocyte antigen class i and II alleles and overall survival in diffuse large B-cell lymphoma and follicular lymphoma

Yani Lu, Amr M. Abdou, James R Cerhan, Lindsay M. Morton, Richard K. Severson, Scott Davis, Wendy Cozen, Nathaniel Rothman, Leslie Bernstein, Stephen Chanock, Patricia Hartge, Sophia S. Wang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 8.1 (HLA A(*)01-B(*)08-DRB1(*)03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31 (52 of 166) DLBCL and 28 (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw(*)07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR]=1.76, 95 confidence interval [CI]=1.01-3.05); HLA-A(*)01:01 was associated with poorer OS (HR=2.23, 95 CI=1.24-4.01), and HLA-DRB1(*)13 (HR=0.12, 95 CI=0.02-0.90) and HLA-B Bw4 (HR=0.36, 95 CI=0.20-0.63) with better OS among FL patients. These results support a role for HLA in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation.

Original languageEnglish (US)
Pages (from-to)2062-2070
Number of pages9
JournalTheScientificWorldJournal
Volume11
DOIs
StatePublished - 2011

Fingerprint

Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
HLA Antigens
antigen
allele
Alleles
Cells
Survival
confidence interval
Hazards
hazard
Confidence Intervals
tumor
Tumor Necrosis Factor-alpha
etiology
Proportional Hazards Models
Non-Hodgkin's Lymphoma
Haplotypes
genetic variation
Lymphoma

Keywords

  • diffuse large B-cell lymphoma
  • follicular lymphoma
  • human leukocyte antigen
  • survival
  • tumor necrosis factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Human leukocyte antigen class i and II alleles and overall survival in diffuse large B-cell lymphoma and follicular lymphoma. / Lu, Yani; Abdou, Amr M.; Cerhan, James R; Morton, Lindsay M.; Severson, Richard K.; Davis, Scott; Cozen, Wendy; Rothman, Nathaniel; Bernstein, Leslie; Chanock, Stephen; Hartge, Patricia; Wang, Sophia S.

In: TheScientificWorldJournal, Vol. 11, 2011, p. 2062-2070.

Research output: Contribution to journalArticle

Lu, Y, Abdou, AM, Cerhan, JR, Morton, LM, Severson, RK, Davis, S, Cozen, W, Rothman, N, Bernstein, L, Chanock, S, Hartge, P & Wang, SS 2011, 'Human leukocyte antigen class i and II alleles and overall survival in diffuse large B-cell lymphoma and follicular lymphoma', TheScientificWorldJournal, vol. 11, pp. 2062-2070. https://doi.org/10.1100/2011/373876
Lu, Yani ; Abdou, Amr M. ; Cerhan, James R ; Morton, Lindsay M. ; Severson, Richard K. ; Davis, Scott ; Cozen, Wendy ; Rothman, Nathaniel ; Bernstein, Leslie ; Chanock, Stephen ; Hartge, Patricia ; Wang, Sophia S. / Human leukocyte antigen class i and II alleles and overall survival in diffuse large B-cell lymphoma and follicular lymphoma. In: TheScientificWorldJournal. 2011 ; Vol. 11. pp. 2062-2070.
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abstract = "Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 8.1 (HLA A(*)01-B(*)08-DRB1(*)03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31 (52 of 166) DLBCL and 28 (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw(*)07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR]=1.76, 95 confidence interval [CI]=1.01-3.05); HLA-A(*)01:01 was associated with poorer OS (HR=2.23, 95 CI=1.24-4.01), and HLA-DRB1(*)13 (HR=0.12, 95 CI=0.02-0.90) and HLA-B Bw4 (HR=0.36, 95 CI=0.20-0.63) with better OS among FL patients. These results support a role for HLA in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation.",
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AU - Lu, Yani

AU - Abdou, Amr M.

AU - Cerhan, James R

AU - Morton, Lindsay M.

AU - Severson, Richard K.

AU - Davis, Scott

AU - Cozen, Wendy

AU - Rothman, Nathaniel

AU - Bernstein, Leslie

AU - Chanock, Stephen

AU - Hartge, Patricia

AU - Wang, Sophia S.

PY - 2011

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N2 - Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 8.1 (HLA A(*)01-B(*)08-DRB1(*)03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31 (52 of 166) DLBCL and 28 (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw(*)07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR]=1.76, 95 confidence interval [CI]=1.01-3.05); HLA-A(*)01:01 was associated with poorer OS (HR=2.23, 95 CI=1.24-4.01), and HLA-DRB1(*)13 (HR=0.12, 95 CI=0.02-0.90) and HLA-B Bw4 (HR=0.36, 95 CI=0.20-0.63) with better OS among FL patients. These results support a role for HLA in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation.

AB - Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 8.1 (HLA A(*)01-B(*)08-DRB1(*)03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31 (52 of 166) DLBCL and 28 (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw(*)07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR]=1.76, 95 confidence interval [CI]=1.01-3.05); HLA-A(*)01:01 was associated with poorer OS (HR=2.23, 95 CI=1.24-4.01), and HLA-DRB1(*)13 (HR=0.12, 95 CI=0.02-0.90) and HLA-B Bw4 (HR=0.36, 95 CI=0.20-0.63) with better OS among FL patients. These results support a role for HLA in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation.

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