Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine: Persistence, dampening, and extinction of associations found after a first dose

Robert M. Jacobson; Inna G. Ovsyannikova; Robert A. Vierkant; V. Shane Pankratz; Gregory A. Poland

doi:10.1016/j.vaccine.2011.08.060

Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine: Persistence, dampening, and extinction of associations found after a first dose

Robert M. Jacobson, Inna G. Ovsyannikova, Robert A. Vierkant, V. Shane Pankratz, Gregory A. Poland

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Previously we found human leukocyte antigen (HLA) associations with humoral immunity following a single dose of measles-containing vaccine. In this study, we sought to determine if HLA associations exist with humoral and cellular immunity following a second dose of measles-containing vaccine and if the associations we found with humoral immunity after the first dose persist following a second dose.We recruited a population-based sample of 346 schoolchildren, all who previously received two doses of a measles-containing vaccine. Molecular HLA classes I and II typing as well as humoral and cellular immune assays (measles-specific IgG antibody levels and lymphoproliferative response) were performed in these subjects.We found significant associations with class I HLA-B (p= 0.05) as well as class II HLA-DPB1 (p= 0.01) and -DPA1 (p= 0.03) genes for measles vaccine-induced antibody levels after the second dose. Similarly, we found significant associations with class II HLA-DQB1 (p= 0.05) and -DRB1 (p= 0.01) genes for measles-specific lymphoproliferation after the second dose.While we found HLA associations after the second dose that we previously found after the first dose of measles containing vaccine, fewer alleles had statistically significant associations, suggesting that the second dose had a dampening or extinguishing effect on the HLA associations. It appears that the second dose overcomes HLA restriction through an as yet unknown mechanism. Future studies of HLA associations should consider both the effect of dose and the role that subsequent doses might play on genetic associations found with the response to a first dose.

Original language	English (US)
Pages (from-to)	7982-7991
Number of pages	10
Journal	Vaccine
Volume	29
Issue number	45
DOIs	https://doi.org/10.1016/j.vaccine.2011.08.060
State	Published - Oct 19 2011

Keywords

Antibody formation
Histocompatibility antigens class I
Histocompatibility antigens class II
Immunogenetics
Lymphocyte activation
Measles antibody
Measles vaccine
Measles-mumps-rubella vaccine

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/j.vaccine.2011.08.060

Fingerprint

Dive into the research topics of 'Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine: Persistence, dampening, and extinction of associations found after a first dose'. Together they form a unique fingerprint.

Cite this

Jacobson, R. M., Ovsyannikova, I. G., Vierkant, R. A., Shane Pankratz, V., & Poland, G. A. (2011). Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine: Persistence, dampening, and extinction of associations found after a first dose. Vaccine, 29(45), 7982-7991. https://doi.org/10.1016/j.vaccine.2011.08.060

Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine: Persistence, dampening, and extinction of associations found after a first dose. / Jacobson, Robert M.; Ovsyannikova, Inna G.; Vierkant, Robert A. et al.
In: Vaccine, Vol. 29, No. 45, 19.10.2011, p. 7982-7991.

Research output: Contribution to journal › Article › peer-review

Jacobson, RM, Ovsyannikova, IG, Vierkant, RA, Shane Pankratz, V & Poland, GA 2011, 'Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine: Persistence, dampening, and extinction of associations found after a first dose', Vaccine, vol. 29, no. 45, pp. 7982-7991. https://doi.org/10.1016/j.vaccine.2011.08.060

@article{43b756619d5c4078acff833986ae0bb4,

title = "Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine: Persistence, dampening, and extinction of associations found after a first dose",

abstract = "Previously we found human leukocyte antigen (HLA) associations with humoral immunity following a single dose of measles-containing vaccine. In this study, we sought to determine if HLA associations exist with humoral and cellular immunity following a second dose of measles-containing vaccine and if the associations we found with humoral immunity after the first dose persist following a second dose.We recruited a population-based sample of 346 schoolchildren, all who previously received two doses of a measles-containing vaccine. Molecular HLA classes I and II typing as well as humoral and cellular immune assays (measles-specific IgG antibody levels and lymphoproliferative response) were performed in these subjects.We found significant associations with class I HLA-B (p= 0.05) as well as class II HLA-DPB1 (p= 0.01) and -DPA1 (p= 0.03) genes for measles vaccine-induced antibody levels after the second dose. Similarly, we found significant associations with class II HLA-DQB1 (p= 0.05) and -DRB1 (p= 0.01) genes for measles-specific lymphoproliferation after the second dose.While we found HLA associations after the second dose that we previously found after the first dose of measles containing vaccine, fewer alleles had statistically significant associations, suggesting that the second dose had a dampening or extinguishing effect on the HLA associations. It appears that the second dose overcomes HLA restriction through an as yet unknown mechanism. Future studies of HLA associations should consider both the effect of dose and the role that subsequent doses might play on genetic associations found with the response to a first dose.",

keywords = "Antibody formation, Histocompatibility antigens class I, Histocompatibility antigens class II, Immunogenetics, Lymphocyte activation, Measles antibody, Measles vaccine, Measles-mumps-rubella vaccine",

author = "Jacobson, {Robert M.} and Ovsyannikova, {Inna G.} and Vierkant, {Robert A.} and {Shane Pankratz}, V. and Poland, {Gregory A.}",

note = "Funding Information: We acknowledge assistance from Richard B. Kennedy, Ph.D. for his critical reading of the manuscript and his suggested revisions. We acknowledge support by Public Health Service grant AI-33144 from the National Institute of Allergy and Infectious Diseases as well as National Institutes of Health/National Center for Research Resources Clinical and Translational Science Awards Grant Number UL1 RR024150 and the Rochester Epidemiology Project (Grant Number R01 AR30582 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases ). ",

year = "2011",

month = oct,

day = "19",

doi = "10.1016/j.vaccine.2011.08.060",

language = "English (US)",

volume = "29",

pages = "7982--7991",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

number = "45",

}

TY - JOUR

T1 - Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine

T2 - Persistence, dampening, and extinction of associations found after a first dose

AU - Jacobson, Robert M.

AU - Ovsyannikova, Inna G.

AU - Vierkant, Robert A.

AU - Shane Pankratz, V.

AU - Poland, Gregory A.

N1 - Funding Information: We acknowledge assistance from Richard B. Kennedy, Ph.D. for his critical reading of the manuscript and his suggested revisions. We acknowledge support by Public Health Service grant AI-33144 from the National Institute of Allergy and Infectious Diseases as well as National Institutes of Health/National Center for Research Resources Clinical and Translational Science Awards Grant Number UL1 RR024150 and the Rochester Epidemiology Project (Grant Number R01 AR30582 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases ).

PY - 2011/10/19

Y1 - 2011/10/19

N2 - Previously we found human leukocyte antigen (HLA) associations with humoral immunity following a single dose of measles-containing vaccine. In this study, we sought to determine if HLA associations exist with humoral and cellular immunity following a second dose of measles-containing vaccine and if the associations we found with humoral immunity after the first dose persist following a second dose.We recruited a population-based sample of 346 schoolchildren, all who previously received two doses of a measles-containing vaccine. Molecular HLA classes I and II typing as well as humoral and cellular immune assays (measles-specific IgG antibody levels and lymphoproliferative response) were performed in these subjects.We found significant associations with class I HLA-B (p= 0.05) as well as class II HLA-DPB1 (p= 0.01) and -DPA1 (p= 0.03) genes for measles vaccine-induced antibody levels after the second dose. Similarly, we found significant associations with class II HLA-DQB1 (p= 0.05) and -DRB1 (p= 0.01) genes for measles-specific lymphoproliferation after the second dose.While we found HLA associations after the second dose that we previously found after the first dose of measles containing vaccine, fewer alleles had statistically significant associations, suggesting that the second dose had a dampening or extinguishing effect on the HLA associations. It appears that the second dose overcomes HLA restriction through an as yet unknown mechanism. Future studies of HLA associations should consider both the effect of dose and the role that subsequent doses might play on genetic associations found with the response to a first dose.

AB - Previously we found human leukocyte antigen (HLA) associations with humoral immunity following a single dose of measles-containing vaccine. In this study, we sought to determine if HLA associations exist with humoral and cellular immunity following a second dose of measles-containing vaccine and if the associations we found with humoral immunity after the first dose persist following a second dose.We recruited a population-based sample of 346 schoolchildren, all who previously received two doses of a measles-containing vaccine. Molecular HLA classes I and II typing as well as humoral and cellular immune assays (measles-specific IgG antibody levels and lymphoproliferative response) were performed in these subjects.We found significant associations with class I HLA-B (p= 0.05) as well as class II HLA-DPB1 (p= 0.01) and -DPA1 (p= 0.03) genes for measles vaccine-induced antibody levels after the second dose. Similarly, we found significant associations with class II HLA-DQB1 (p= 0.05) and -DRB1 (p= 0.01) genes for measles-specific lymphoproliferation after the second dose.While we found HLA associations after the second dose that we previously found after the first dose of measles containing vaccine, fewer alleles had statistically significant associations, suggesting that the second dose had a dampening or extinguishing effect on the HLA associations. It appears that the second dose overcomes HLA restriction through an as yet unknown mechanism. Future studies of HLA associations should consider both the effect of dose and the role that subsequent doses might play on genetic associations found with the response to a first dose.

KW - Antibody formation

KW - Histocompatibility antigens class I

KW - Histocompatibility antigens class II

KW - Immunogenetics

KW - Lymphocyte activation

KW - Measles antibody

KW - Measles vaccine

KW - Measles-mumps-rubella vaccine

UR - http://www.scopus.com/inward/record.url?scp=80053642761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053642761&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2011.08.060

DO - 10.1016/j.vaccine.2011.08.060

M3 - Article

C2 - 21872631

AN - SCOPUS:80053642761

SN - 0264-410X

VL - 29

SP - 7982

EP - 7991

JO - Vaccine

JF - Vaccine

IS - 45

ER -

Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine: Persistence, dampening, and extinction of associations found after a first dose

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this