Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction

Yan Wang, Gang Pei, Y. C. Cai, Z. Q. Zhao, J. B. Wang, C. L. Jiang, Z. C. Zheng, X. Y. Liu

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Interleukin-2 (IL-2) was found to have an analgesic effect in the peripheral nervous system. Both electrophysiological and behavioural experiments suggested an anti-nociceptive effect of IL-2 in animals. Biochemical experiments revealed that IL-2 could displace diprenorphine binding in both NG 108-15 cells and HEK 293 cells transfected with pCDNA3-DOR (δ opioid receptor). Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the δ opioid receptor is functional.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalNeuroReport
Volume8
Issue number1
DOIs
StatePublished - 1997

Keywords

  • Analgesic effect
  • Human interleukin-2 (IL-2)
  • Opioid receptor
  • Pain threshold (PT)
  • Signal transduction
  • cAMP production

ASJC Scopus subject areas

  • Neuroscience(all)

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    Wang, Y., Pei, G., Cai, Y. C., Zhao, Z. Q., Wang, J. B., Jiang, C. L., Zheng, Z. C., & Liu, X. Y. (1997). Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction. NeuroReport, 8(1), 11-14. https://doi.org/10.1097/00001756-199612200-00003