Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction

Yan Wang; Gang Pei; Y. C. Cai; Z. Q. Zhao; J. B. Wang; C. L. Jiang; Z. C. Zheng; X. Y. Liu

doi:10.1097/00001756-199612200-00003

Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction

Yan Wang, Gang Pei, Y. C. Cai, Z. Q. Zhao, J. B. Wang, C. L. Jiang, Z. C. Zheng, X. Y. Liu

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Interleukin-2 (IL-2) was found to have an analgesic effect in the peripheral nervous system. Both electrophysiological and behavioural experiments suggested an anti-nociceptive effect of IL-2 in animals. Biochemical experiments revealed that IL-2 could displace diprenorphine binding in both NG 108-15 cells and HEK 293 cells transfected with pCDNA3-DOR (δ opioid receptor). Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the δ opioid receptor is functional.

Original language	English (US)
Pages (from-to)	11-14
Number of pages	4
Journal	NeuroReport
Volume	8
Issue number	1
DOIs	https://doi.org/10.1097/00001756-199612200-00003
State	Published - 1997

Keywords

Analgesic effect
Human interleukin-2 (IL-2)
Opioid receptor
Pain threshold (PT)
Signal transduction
cAMP production

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199612200-00003

Cite this

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abstract = "Interleukin-2 (IL-2) was found to have an analgesic effect in the peripheral nervous system. Both electrophysiological and behavioural experiments suggested an anti-nociceptive effect of IL-2 in animals. Biochemical experiments revealed that IL-2 could displace diprenorphine binding in both NG 108-15 cells and HEK 293 cells transfected with pCDNA3-DOR (δ opioid receptor). Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the δ opioid receptor is functional.",

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author = "Yan Wang and Gang Pei and Cai, {Y. C.} and Zhao, {Z. Q.} and Wang, {J. B.} and Jiang, {C. L.} and Zheng, {Z. C.} and Liu, {X. Y.}",

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T1 - Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction

AU - Wang, Yan

AU - Pei, Gang

AU - Cai, Y. C.

AU - Zhao, Z. Q.

AU - Wang, J. B.

AU - Jiang, C. L.

AU - Zheng, Z. C.

AU - Liu, X. Y.

PY - 1997

Y1 - 1997

N2 - Interleukin-2 (IL-2) was found to have an analgesic effect in the peripheral nervous system. Both electrophysiological and behavioural experiments suggested an anti-nociceptive effect of IL-2 in animals. Biochemical experiments revealed that IL-2 could displace diprenorphine binding in both NG 108-15 cells and HEK 293 cells transfected with pCDNA3-DOR (δ opioid receptor). Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the δ opioid receptor is functional.

AB - Interleukin-2 (IL-2) was found to have an analgesic effect in the peripheral nervous system. Both electrophysiological and behavioural experiments suggested an anti-nociceptive effect of IL-2 in animals. Biochemical experiments revealed that IL-2 could displace diprenorphine binding in both NG 108-15 cells and HEK 293 cells transfected with pCDNA3-DOR (δ opioid receptor). Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the δ opioid receptor is functional.

KW - Analgesic effect

KW - Human interleukin-2 (IL-2)

KW - Opioid receptor

KW - Pain threshold (PT)

KW - Signal transduction

KW - cAMP production

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Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction

Abstract

Keywords

ASJC Scopus subject areas

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