Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction

Yan Asmann, Gang Pei, Y. C. Cai, Z. Q. Zhao, J. B. Wang, C. L. Jiang, Z. C. Zheng, X. Y. Liu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Interleukin-2 (IL-2) was found to have an analgesic effect in the peripheral nervous system. Both electrophysiological and behavioural experiments suggested an anti-nociceptive effect of IL-2 in animals. Biochemical experiments revealed that IL-2 could displace diprenorphine binding in both NG 108-15 cells and HEK 293 cells transfected with pCDNA3-DOR (δ opioid receptor). Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the δ opioid receptor is functional.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalNeuroReport
Volume8
Issue number1
StatePublished - 1997
Externally publishedYes

Fingerprint

Opioid Receptors
Interleukin-2
Signal Transduction
HEK293 Cells
Diprenorphine
Peripheral Nervous System
Colforsin
Analgesics

Keywords

  • Analgesic effect
  • cAMP production
  • Human interleukin-2 (IL-2)
  • Opioid receptor
  • Pain threshold (PT)
  • Signal transduction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Asmann, Y., Pei, G., Cai, Y. C., Zhao, Z. Q., Wang, J. B., Jiang, C. L., ... Liu, X. Y. (1997). Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction. NeuroReport, 8(1), 11-14.

Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction. / Asmann, Yan; Pei, Gang; Cai, Y. C.; Zhao, Z. Q.; Wang, J. B.; Jiang, C. L.; Zheng, Z. C.; Liu, X. Y.

In: NeuroReport, Vol. 8, No. 1, 1997, p. 11-14.

Research output: Contribution to journalArticle

Asmann, Y, Pei, G, Cai, YC, Zhao, ZQ, Wang, JB, Jiang, CL, Zheng, ZC & Liu, XY 1997, 'Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction', NeuroReport, vol. 8, no. 1, pp. 11-14.
Asmann, Yan ; Pei, Gang ; Cai, Y. C. ; Zhao, Z. Q. ; Wang, J. B. ; Jiang, C. L. ; Zheng, Z. C. ; Liu, X. Y. / Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction. In: NeuroReport. 1997 ; Vol. 8, No. 1. pp. 11-14.
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