Human infection with ehrlichia muris–like pathogen, United States, 2007–2013

Diep K.Hoang Johnson; Elizabeth K. Schiffman; Jeffrey P. Davis; David F. Neitzel; Lynne M. Sloan; William L. Nicholson; Thomas R. Fritsche; Christopher R. Steward; Julie A. Ray; Tracy K. Miller; Michelle A. Feist; Timothy S. Uphoff; Joni J. Franson; Amy L. Livermore; Alecia K. Deedon; Elitza S. Theel; Bobbi S. Pritt

doi:10.3201/eid2110.150143

Human infection with ehrlichia muris–like pathogen, United States, 2007–2013

Diep K.Hoang Johnson, Elizabeth K. Schiffman, Jeffrey P. Davis, David F. Neitzel, Lynne M. Sloan, William L. Nicholson, Thomas R. Fritsche, Christopher R. Steward, Julie A. Ray, Tracy K. Miller, Michelle A. Feist, Timothy S. Uphoff, Joni J. Franson, Amy L. Livermore, Alecia K. Deedon, Elitza S. Theel, Bobbi S. Pritt

Laboratory Medicine and Pathology

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39 Scopus citations

Abstract

An Ehrlichia muris–like (EML) pathogen was detected among 4 patients in Minnesota and Wisconsin during 2009. We characterized additional cases clinically and epidemiologically. During 2004–2013, blood samples from 75,077 patients from all 50 United States were tested by PCR from the groEL gene for Ehrlichia spp. and Anaplasma phagocytophilum. During 2007–2013, samples from 69 (0.1%) patients were positive for the EML pathogen; patients were from 5 states: Indiana (1), Michigan (1), Minnesota (33), North Dakota (3), and Wisconsin (31). Most (64%) patients were male; median age was 63 (range 15–94) years; and all 69 patients reported likely tick exposure in Minnesota or Wisconsin. Fever, malaise, thrombocytopenia, and lymphopenia were the most common symptoms. Sixteen (23%) patients were hospitalized (median 4 days); all recovered, and 96% received doxycycline. Infection with the EML pathogen should be considered for persons reporting tick exposure in Minnesota or Wisconsin.

Original language	English (US)
Pages (from-to)	1794-1799
Number of pages	6
Journal	Emerging infectious diseases
Volume	21
Issue number	10
DOIs	https://doi.org/10.3201/eid2110.150143
State	Published - Sep 1 2015

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Johnson, D. K. H., Schiffman, E. K., Davis, J. P., Neitzel, D. F., Sloan, L. M., Nicholson, W. L., Fritsche, T. R., Steward, C. R., Ray, J. A., Miller, T. K., Feist, M. A., Uphoff, T. S., Franson, J. J., Livermore, A. L., Deedon, A. K., Theel, E. S., & Pritt, B. S. (2015). Human infection with ehrlichia muris–like pathogen, United States, 2007–2013. Emerging infectious diseases, 21(10), 1794-1799. https://doi.org/10.3201/eid2110.150143

Johnson, DKH, Schiffman, EK, Davis, JP, Neitzel, DF, Sloan, LM, Nicholson, WL, Fritsche, TR, Steward, CR, Ray, JA, Miller, TK, Feist, MA, Uphoff, TS, Franson, JJ, Livermore, AL, Deedon, AK, Theel, ES & Pritt, BS 2015, 'Human infection with ehrlichia muris–like pathogen, United States, 2007–2013', Emerging infectious diseases, vol. 21, no. 10, pp. 1794-1799. https://doi.org/10.3201/eid2110.150143

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title = "Human infection with ehrlichia muris–like pathogen, United States, 2007–2013",

abstract = "An Ehrlichia muris–like (EML) pathogen was detected among 4 patients in Minnesota and Wisconsin during 2009. We characterized additional cases clinically and epidemiologically. During 2004–2013, blood samples from 75,077 patients from all 50 United States were tested by PCR from the groEL gene for Ehrlichia spp. and Anaplasma phagocytophilum. During 2007–2013, samples from 69 (0.1%) patients were positive for the EML pathogen; patients were from 5 states: Indiana (1), Michigan (1), Minnesota (33), North Dakota (3), and Wisconsin (31). Most (64%) patients were male; median age was 63 (range 15–94) years; and all 69 patients reported likely tick exposure in Minnesota or Wisconsin. Fever, malaise, thrombocytopenia, and lymphopenia were the most common symptoms. Sixteen (23%) patients were hospitalized (median 4 days); all recovered, and 96% received doxycycline. Infection with the EML pathogen should be considered for persons reporting tick exposure in Minnesota or Wisconsin.",

author = "Johnson, {Diep K.Hoang} and Schiffman, {Elizabeth K.} and Davis, {Jeffrey P.} and Neitzel, {David F.} and Sloan, {Lynne M.} and Nicholson, {William L.} and Fritsche, {Thomas R.} and Steward, {Christopher R.} and Ray, {Julie A.} and Miller, {Tracy K.} and Feist, {Michelle A.} and Uphoff, {Timothy S.} and Franson, {Joni J.} and Livermore, {Amy L.} and Deedon, {Alecia K.} and Theel, {Elitza S.} and Pritt, {Bobbi S.}",

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Human infection with ehrlichia muris–like pathogen, United States, 2007–2013

Abstract

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