TY - JOUR
T1 - Human Gut Microbiota in Coronary Artery Disease
T2 - A Systematic Review and Meta-Analysis †
AU - Choroszy, Marcin
AU - Litwinowicz, Kamil
AU - Bednarz, Robert
AU - Roleder, Tomasz
AU - Lerman, Amir
AU - Toya, Takumi
AU - Kamiński, Karol
AU - Sawicka-Śmiarowska, Emilia
AU - Niemira, Magdalena
AU - Sobieszczańska, Beata
N1 - Funding Information:
The publication was prepared under the project financed from the funds granted by the Ministry of Education and Science in the “Regional Initiative of Excellence” program for the years 2019–2022, project number 016/RID/2018/19 (individual project number RID Z501.20.009). The part of the data was funded by National Science Centre, Poland project no.: 2017/25/N/NZ5/02765.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/12
Y1 - 2022/12
N2 - In recent years, the importance of the gut microbiome in human health and disease has increased. Growing evidence suggests that gut dysbiosis might be a crucial risk factor for coronary artery disease (CAD). Therefore, we conducted a systematic review and meta-analysis to determine whether or not CAD is associated with specific changes in the gut microbiome. The V3–V4 regions of the 16S rDNA from fecal samples were analyzed to compare the gut microbiome composition between CAD patients and controls. Our search yielded 1181 articles, of which 21 met inclusion criteria for systematic review and 7 for meta-analysis. The alpha-diversity, including observed OTUs, Shannon and Simpson indices, was significantly decreased in CAD, indicating the reduced richness of the gut microbiome. The most consistent results in a systematic review and meta-analysis pointed out the reduced abundance of Bacteroidetes and Lachnospiraceae in CAD patients. Moreover, Enterobacteriaceae, Lactobacillus, and Streptococcus taxa demonstrated an increased trend in CAD patients. The alterations in the gut microbiota composition are associated with qualitative and quantitative changes in bacterial metabolites, many of which have pro-atherogenic effects on endothelial cells, increasing the risk of developing and progressing CAD.
AB - In recent years, the importance of the gut microbiome in human health and disease has increased. Growing evidence suggests that gut dysbiosis might be a crucial risk factor for coronary artery disease (CAD). Therefore, we conducted a systematic review and meta-analysis to determine whether or not CAD is associated with specific changes in the gut microbiome. The V3–V4 regions of the 16S rDNA from fecal samples were analyzed to compare the gut microbiome composition between CAD patients and controls. Our search yielded 1181 articles, of which 21 met inclusion criteria for systematic review and 7 for meta-analysis. The alpha-diversity, including observed OTUs, Shannon and Simpson indices, was significantly decreased in CAD, indicating the reduced richness of the gut microbiome. The most consistent results in a systematic review and meta-analysis pointed out the reduced abundance of Bacteroidetes and Lachnospiraceae in CAD patients. Moreover, Enterobacteriaceae, Lactobacillus, and Streptococcus taxa demonstrated an increased trend in CAD patients. The alterations in the gut microbiota composition are associated with qualitative and quantitative changes in bacterial metabolites, many of which have pro-atherogenic effects on endothelial cells, increasing the risk of developing and progressing CAD.
KW - atherosclerosis
KW - coronary artery disease
KW - dysbiosis
KW - gut microbiome
KW - LPS
KW - SCFA
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U2 - 10.3390/metabo12121165
DO - 10.3390/metabo12121165
M3 - Review article
AN - SCOPUS:85144730219
SN - 2218-1989
VL - 12
JO - Metabolites
JF - Metabolites
IS - 12
M1 - 1165
ER -