Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease

Ashutosh Mangalam, Shailesh K. Shahi, David Luckey, Melissa Karau, Eric Marietta, Ningling Luo, Rok Seon Choung, Josephine Ju, Ramakrishna Sompallae, Katherine Gibson-Corley, Robin Patel, Moses Rodriguez, Chella David, Veena D Taneja, Joseph A Murray

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The human gut is colonized by a large number of microorganisms (∼1013 bacteria) that support various physiologic functions. A perturbation in the healthy gut microbiome might lead to the development of inflammatory diseases, such as multiple sclerosis (MS). Therefore, gut commensals might provide promising therapeutic options for treating MS and other diseases. We report the identification of human gut-derived commensal bacteria, Prevotella histicola, which can suppress experimental autoimmune encephalomyelitis (EAE) in a human leukocyte antigen (HLA) class II transgenic mouse model. P. histicola suppresses disease through the modulation of systemic immune responses. P. histicola challenge led to a decrease in pro-inflammatory Th1 and Th17 cells and an increase in the frequencies of CD4+FoxP3+ regulatory T cells, tolerogenic dendritic cells, and suppressive macrophages. Our study provides evidence that the administration of gut commensals may regulate a systemic immune response and may, therefore, have a possible role in treatment strategies for MS.

Original languageEnglish (US)
Pages (from-to)1269-1277
Number of pages9
JournalCell Reports
Volume20
Issue number6
DOIs
StatePublished - Aug 8 2017

Fingerprint

Central Nervous System Diseases
Demyelinating Diseases
Multiple Sclerosis
Bacteria
Prevotella
Th17 Cells
Forensic Anthropology
Th1 Cells
T-cells
Autoimmune Experimental Encephalomyelitis
Macrophages
Regulatory T-Lymphocytes
HLA Antigens
Microorganisms
Dendritic Cells
Transgenic Mice
Modulation
Therapeutics

Keywords

  • demyelination
  • EAE
  • experimental autoimmune encephalomyelitis
  • gut microbiome
  • human commensal
  • immunomodulation
  • inflammation
  • multiple sclerosis
  • Prevotella histicola
  • regulatory T cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease. / Mangalam, Ashutosh; Shahi, Shailesh K.; Luckey, David; Karau, Melissa; Marietta, Eric; Luo, Ningling; Choung, Rok Seon; Ju, Josephine; Sompallae, Ramakrishna; Gibson-Corley, Katherine; Patel, Robin; Rodriguez, Moses; David, Chella; Taneja, Veena D; Murray, Joseph A.

In: Cell Reports, Vol. 20, No. 6, 08.08.2017, p. 1269-1277.

Research output: Contribution to journalArticle

Mangalam, A, Shahi, SK, Luckey, D, Karau, M, Marietta, E, Luo, N, Choung, RS, Ju, J, Sompallae, R, Gibson-Corley, K, Patel, R, Rodriguez, M, David, C, Taneja, VD & Murray, JA 2017, 'Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease', Cell Reports, vol. 20, no. 6, pp. 1269-1277. https://doi.org/10.1016/j.celrep.2017.07.031
Mangalam A, Shahi SK, Luckey D, Karau M, Marietta E, Luo N et al. Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease. Cell Reports. 2017 Aug 8;20(6):1269-1277. https://doi.org/10.1016/j.celrep.2017.07.031
Mangalam, Ashutosh ; Shahi, Shailesh K. ; Luckey, David ; Karau, Melissa ; Marietta, Eric ; Luo, Ningling ; Choung, Rok Seon ; Ju, Josephine ; Sompallae, Ramakrishna ; Gibson-Corley, Katherine ; Patel, Robin ; Rodriguez, Moses ; David, Chella ; Taneja, Veena D ; Murray, Joseph A. / Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease. In: Cell Reports. 2017 ; Vol. 20, No. 6. pp. 1269-1277.
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