Abstract
The human gut is colonized by a large number of microorganisms (∼1013 bacteria) that support various physiologic functions. A perturbation in the healthy gut microbiome might lead to the development of inflammatory diseases, such as multiple sclerosis (MS). Therefore, gut commensals might provide promising therapeutic options for treating MS and other diseases. We report the identification of human gut-derived commensal bacteria, Prevotella histicola, which can suppress experimental autoimmune encephalomyelitis (EAE) in a human leukocyte antigen (HLA) class II transgenic mouse model. P. histicola suppresses disease through the modulation of systemic immune responses. P. histicola challenge led to a decrease in pro-inflammatory Th1 and Th17 cells and an increase in the frequencies of CD4+FoxP3+ regulatory T cells, tolerogenic dendritic cells, and suppressive macrophages. Our study provides evidence that the administration of gut commensals may regulate a systemic immune response and may, therefore, have a possible role in treatment strategies for MS.
Original language | English (US) |
---|---|
Pages (from-to) | 1269-1277 |
Number of pages | 9 |
Journal | Cell reports |
Volume | 20 |
Issue number | 6 |
DOIs | |
State | Published - Aug 8 2017 |
Keywords
- EAE
- Prevotella histicola
- demyelination
- experimental autoimmune encephalomyelitis
- gut microbiome
- human commensal
- immunomodulation
- inflammation
- multiple sclerosis
- regulatory T cells
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology