Human gastric emptying and colonic filling of solids characterized by a new method

Michael Camilleri, L. J. Colemont, S. F. Phillips, M. L. Brown, G. M. Thomforde, N. Chapman, A. R. Zinsmeister

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Our first aim was to compare 111In-labeled Amberlite IR-12OP resin pellets and 131I-labeled fiber in the assessment of gastric and small bowel transit and colonic filling in healthy humans. Both radiolabels were highly stable for 3 h in an in vitro stomach model and remained predominantly bound to solid phase of stools collected over 5 days [90.5 ± 2.1 (SE)% for 131I and 87.4 ± 1.4% for 111In). The lag phase of gastric emptying was shorter for 111In-pellets (30 ± 11 min compared with 58 ± 12 min for 131I-fiber, P < 0.05). However, the slope of the postlag phase of gastric emptying and the half time of small bowel transit were not significantly different for 111In-pellets and 131I-fiber. Filling of the colon was characterized by bolus movements of the radiolabel (10-80% range, 26% mean) followed by plateaus (periods of no movement of isotope into colon lasting 15-120 min, range; 51 min, mean). Half of the bolus movements occurred within 1 h of the intake of a second meal. Thus 111In-labeled Amberlite pellets provide an excellent marker for the study of gastric and small bowel transit and colonic filling in humans. The ileum acts as a reservoir and transfers boluses of variable sizes into the colon, often soon after the intake of a subsequent meal.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume257
Issue number2
StatePublished - 1989

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Gastric Emptying
Stomach
Colon
Meals
Ileum
Isotopes
amberlite

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Camilleri, M., Colemont, L. J., Phillips, S. F., Brown, M. L., Thomforde, G. M., Chapman, N., & Zinsmeister, A. R. (1989). Human gastric emptying and colonic filling of solids characterized by a new method. American Journal of Physiology - Gastrointestinal and Liver Physiology, 257(2).

Human gastric emptying and colonic filling of solids characterized by a new method. / Camilleri, Michael; Colemont, L. J.; Phillips, S. F.; Brown, M. L.; Thomforde, G. M.; Chapman, N.; Zinsmeister, A. R.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 257, No. 2, 1989.

Research output: Contribution to journalArticle

Camilleri, M, Colemont, LJ, Phillips, SF, Brown, ML, Thomforde, GM, Chapman, N & Zinsmeister, AR 1989, 'Human gastric emptying and colonic filling of solids characterized by a new method', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 257, no. 2.
Camilleri, Michael ; Colemont, L. J. ; Phillips, S. F. ; Brown, M. L. ; Thomforde, G. M. ; Chapman, N. ; Zinsmeister, A. R. / Human gastric emptying and colonic filling of solids characterized by a new method. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 1989 ; Vol. 257, No. 2.
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