Human gastric emptying and colonic filling of solids characterized by a new method

M. Camilleri, L. J. Colemont, S. F. Phillips, M. L. Brown, G. M. Thomforde, N. Chapman, A. R. Zinsmeister

Research output: Contribution to journalArticle

189 Scopus citations

Abstract

Our first aim was to compare 111In-labeled Amberlite IR-12OP resin pellets and 131I-labeled fiber in the assessment of gastric and small bowel transit and colonic filling in healthy humans. Both radiolabels were highly stable for 3 h in an in vitro stomach model and remained predominantly bound to solid phase of stools collected over 5 days [90.5 ± 2.1 (SE)% for 131I and 87.4 ± 1.4% for 111In). The lag phase of gastric emptying was shorter for 111In-pellets (30 ± 11 min compared with 58 ± 12 min for 131I-fiber, P < 0.05). However, the slope of the postlag phase of gastric emptying and the half time of small bowel transit were not significantly different for 111In-pellets and 131I-fiber. Filling of the colon was characterized by bolus movements of the radiolabel (10-80% range, 26% mean) followed by plateaus (periods of no movement of isotope into colon lasting 15-120 min, range; 51 min, mean). Half of the bolus movements occurred within 1 h of the intake of a second meal. Thus 111In-labeled Amberlite pellets provide an excellent marker for the study of gastric and small bowel transit and colonic filling in humans. The ileum acts as a reservoir and transfers boluses of variable sizes into the colon, often soon after the intake of a subsequent meal.

Original languageEnglish (US)
Pages (from-to)20/2
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume257
Issue number2
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Human gastric emptying and colonic filling of solids characterized by a new method'. Together they form a unique fingerprint.

  • Cite this

    Camilleri, M., Colemont, L. J., Phillips, S. F., Brown, M. L., Thomforde, G. M., Chapman, N., & Zinsmeister, A. R. (1989). Human gastric emptying and colonic filling of solids characterized by a new method. American Journal of Physiology - Gastrointestinal and Liver Physiology, 257(2), 20/2.