Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry

Peter J Dyck, W. R. Sherman, L. M. Hallcher, F. J. Service, P. C. O'Brien, L. A. Grina, P. J. Palumbo, C. J. Swanson

Research output: Contribution to journalArticle

416 Citations (Scopus)

Abstract

Fascicles of the sural nerve from each of 20 diabetic patients, mostly with maturity-onset diabetes, were studied by biochemical and pathological techniques, and results were compared to values found in nerve specimens from 15 healthy persons. The sorbitol and fructose content was much more variable in diabetic than in healthy nerves. More than one-third of the diabetic nerves had sorbitol and fructose values above the highest levels for controls. myo-Inositol and scyllo-inositol content was not reduced in diabetic nerves. The sorbitol, fructose, and inositol concentrations could not be related to clinical, neurophysiological, or pathological severity of neuropathy. A comparison of scored symptoms and signs and clinical neurophysiological studies against morphometric and teased fiber studies of sural nerve demonstrated that the former three provide sensitive and reliable measures of severity of neuropathy that can be used for controlled clinical trials of diabetic neuropathy. The presence and type of teased fiber abnormalities could be related to the duration of diabetes and to symptoms of neuropathy. In untreated diabetics without symptoms of neuropathy, a higher than normal frequency of teased fibers showing segmental demyelination and remyelination was found. Untreated diabetics with symptomatic neuropathy showed two kinds of abnormalities: fibers with segmental demyelination and remyelination and fibers undergoing axonal degeneration. In treated diabetics, who often had longstanding neuropathy, the most common abnormalities were fiber undergoing axonal degeneration.

Original languageEnglish (US)
Pages (from-to)590-596
Number of pages7
JournalAnnals of Neurology
Volume8
Issue number6
DOIs
StatePublished - 1980

Fingerprint

Sural Nerve
Sorbitol
Inositol
Fructose
Demyelinating Diseases
Diabetic Neuropathies
Controlled Clinical Trials
Type 2 Diabetes Mellitus
Signs and Symptoms

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dyck, P. J., Sherman, W. R., Hallcher, L. M., Service, F. J., O'Brien, P. C., Grina, L. A., ... Swanson, C. J. (1980). Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry. Annals of Neurology, 8(6), 590-596. https://doi.org/10.1002/ana.410080608

Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry. / Dyck, Peter J; Sherman, W. R.; Hallcher, L. M.; Service, F. J.; O'Brien, P. C.; Grina, L. A.; Palumbo, P. J.; Swanson, C. J.

In: Annals of Neurology, Vol. 8, No. 6, 1980, p. 590-596.

Research output: Contribution to journalArticle

Dyck, PJ, Sherman, WR, Hallcher, LM, Service, FJ, O'Brien, PC, Grina, LA, Palumbo, PJ & Swanson, CJ 1980, 'Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry', Annals of Neurology, vol. 8, no. 6, pp. 590-596. https://doi.org/10.1002/ana.410080608
Dyck, Peter J ; Sherman, W. R. ; Hallcher, L. M. ; Service, F. J. ; O'Brien, P. C. ; Grina, L. A. ; Palumbo, P. J. ; Swanson, C. J. / Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry. In: Annals of Neurology. 1980 ; Vol. 8, No. 6. pp. 590-596.
@article{8af22ed35eb9489b9e48db31acd78f79,
title = "Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry",
abstract = "Fascicles of the sural nerve from each of 20 diabetic patients, mostly with maturity-onset diabetes, were studied by biochemical and pathological techniques, and results were compared to values found in nerve specimens from 15 healthy persons. The sorbitol and fructose content was much more variable in diabetic than in healthy nerves. More than one-third of the diabetic nerves had sorbitol and fructose values above the highest levels for controls. myo-Inositol and scyllo-inositol content was not reduced in diabetic nerves. The sorbitol, fructose, and inositol concentrations could not be related to clinical, neurophysiological, or pathological severity of neuropathy. A comparison of scored symptoms and signs and clinical neurophysiological studies against morphometric and teased fiber studies of sural nerve demonstrated that the former three provide sensitive and reliable measures of severity of neuropathy that can be used for controlled clinical trials of diabetic neuropathy. The presence and type of teased fiber abnormalities could be related to the duration of diabetes and to symptoms of neuropathy. In untreated diabetics without symptoms of neuropathy, a higher than normal frequency of teased fibers showing segmental demyelination and remyelination was found. Untreated diabetics with symptomatic neuropathy showed two kinds of abnormalities: fibers with segmental demyelination and remyelination and fibers undergoing axonal degeneration. In treated diabetics, who often had longstanding neuropathy, the most common abnormalities were fiber undergoing axonal degeneration.",
author = "Dyck, {Peter J} and Sherman, {W. R.} and Hallcher, {L. M.} and Service, {F. J.} and O'Brien, {P. C.} and Grina, {L. A.} and Palumbo, {P. J.} and Swanson, {C. J.}",
year = "1980",
doi = "10.1002/ana.410080608",
language = "English (US)",
volume = "8",
pages = "590--596",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry

AU - Dyck, Peter J

AU - Sherman, W. R.

AU - Hallcher, L. M.

AU - Service, F. J.

AU - O'Brien, P. C.

AU - Grina, L. A.

AU - Palumbo, P. J.

AU - Swanson, C. J.

PY - 1980

Y1 - 1980

N2 - Fascicles of the sural nerve from each of 20 diabetic patients, mostly with maturity-onset diabetes, were studied by biochemical and pathological techniques, and results were compared to values found in nerve specimens from 15 healthy persons. The sorbitol and fructose content was much more variable in diabetic than in healthy nerves. More than one-third of the diabetic nerves had sorbitol and fructose values above the highest levels for controls. myo-Inositol and scyllo-inositol content was not reduced in diabetic nerves. The sorbitol, fructose, and inositol concentrations could not be related to clinical, neurophysiological, or pathological severity of neuropathy. A comparison of scored symptoms and signs and clinical neurophysiological studies against morphometric and teased fiber studies of sural nerve demonstrated that the former three provide sensitive and reliable measures of severity of neuropathy that can be used for controlled clinical trials of diabetic neuropathy. The presence and type of teased fiber abnormalities could be related to the duration of diabetes and to symptoms of neuropathy. In untreated diabetics without symptoms of neuropathy, a higher than normal frequency of teased fibers showing segmental demyelination and remyelination was found. Untreated diabetics with symptomatic neuropathy showed two kinds of abnormalities: fibers with segmental demyelination and remyelination and fibers undergoing axonal degeneration. In treated diabetics, who often had longstanding neuropathy, the most common abnormalities were fiber undergoing axonal degeneration.

AB - Fascicles of the sural nerve from each of 20 diabetic patients, mostly with maturity-onset diabetes, were studied by biochemical and pathological techniques, and results were compared to values found in nerve specimens from 15 healthy persons. The sorbitol and fructose content was much more variable in diabetic than in healthy nerves. More than one-third of the diabetic nerves had sorbitol and fructose values above the highest levels for controls. myo-Inositol and scyllo-inositol content was not reduced in diabetic nerves. The sorbitol, fructose, and inositol concentrations could not be related to clinical, neurophysiological, or pathological severity of neuropathy. A comparison of scored symptoms and signs and clinical neurophysiological studies against morphometric and teased fiber studies of sural nerve demonstrated that the former three provide sensitive and reliable measures of severity of neuropathy that can be used for controlled clinical trials of diabetic neuropathy. The presence and type of teased fiber abnormalities could be related to the duration of diabetes and to symptoms of neuropathy. In untreated diabetics without symptoms of neuropathy, a higher than normal frequency of teased fibers showing segmental demyelination and remyelination was found. Untreated diabetics with symptomatic neuropathy showed two kinds of abnormalities: fibers with segmental demyelination and remyelination and fibers undergoing axonal degeneration. In treated diabetics, who often had longstanding neuropathy, the most common abnormalities were fiber undergoing axonal degeneration.

UR - http://www.scopus.com/inward/record.url?scp=0019161221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019161221&partnerID=8YFLogxK

U2 - 10.1002/ana.410080608

DO - 10.1002/ana.410080608

M3 - Article

VL - 8

SP - 590

EP - 596

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 6

ER -