Human-derived natural antibodies: Biomarkers and potential therapeutics

Xiaohua Xu, Sher May Ng, Eamonn Hassouna, Arthur Warrington, Sang Hyun Oh, Moses Rodriguez

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

The immune system generates antibodies and antigen-specific T-cells as basic elements of the immune networks that differentiate self from non-self in a finely tuned manner. The antigen-specific nature of immune responses ensures that normal immune activation contains non-self when tolerating self. Here we review the B-1 subset of lymphocytes which produce self-reactive antibodies. By analyzing the IgM class of natural antibodies that recognize antigens from the nervous system, we emphasize that natural antibodies are biomarkers of how the immune system monitors the host. The immune response activated against self can be detrimental when triggered in an autoimmune genetic background. In contrast, tuning immune activity with natural antibodies is a potential therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)25-39
Number of pages15
JournalFuture Neurology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2015

    Fingerprint

Keywords

  • B-1 cell
  • CNS inflammation
  • T-cell activation
  • autoimmunity
  • natural auto-antibody

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Xu, X., Ng, S. M., Hassouna, E., Warrington, A., Oh, S. H., & Rodriguez, M. (2015). Human-derived natural antibodies: Biomarkers and potential therapeutics. Future Neurology, 10(1), 25-39. https://doi.org/10.2217/fnl.14.62