Human bone marrow: A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function

Xiaoyu Zhang, Haidong M Dong, Wei Lin, Stephen Voss, Lucinda Hinkley, Melissa Westergren, Guoliang Tian, Daniel Berry, David Lewellen, Richard Geoffrey Vile, Lieping Chen, Donna L. Farber, Scott E. Strome

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The role of human bone marrow (BM) CD8+ T cells in the immune response to viral Ags is poorly defined. We report here the identification and characterization of a functionally enhanced effector memory CD8+ T cell population (TEM) in the BM of patients undergoing total joint replacement for osteoarthritis. These BM-derived TEM differ strikingly from correlate cells in peripheral blood (PB), expressing elevated levels of CD27, HLA-DR, CD38, CD69, and unique patterns of chemokine receptors. Interestingly, while BM TEM have low levels of resting perform and granzyme B, these molecules evidence profound up-regulation in response to TCR stimulation resulting in enhanced cytotoxic potential. Moreover, compared with the TEM subset in PB, BM CD8+ TEM cells demonstrate a more vigorous recall response to pooled viral Ags. Our results reveal that human BM serves as a repository for viral Ag-spccific TEM with great therapeutic potential in vaccine development.

Original languageEnglish (US)
Pages (from-to)6730-6737
Number of pages8
JournalJournal of Immunology
Volume177
Issue number10
StatePublished - Nov 15 2006

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Bone Marrow
T-Lymphocytes
Replacement Arthroplasties
Granzymes
Chemokine Receptors
HLA-DR Antigens
Osteoarthritis
Up-Regulation
Vaccines
Population
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Zhang, X., Dong, H. M., Lin, W., Voss, S., Hinkley, L., Westergren, M., ... Strome, S. E. (2006). Human bone marrow: A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function. Journal of Immunology, 177(10), 6730-6737.

Human bone marrow : A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function. / Zhang, Xiaoyu; Dong, Haidong M; Lin, Wei; Voss, Stephen; Hinkley, Lucinda; Westergren, Melissa; Tian, Guoliang; Berry, Daniel; Lewellen, David; Vile, Richard Geoffrey; Chen, Lieping; Farber, Donna L.; Strome, Scott E.

In: Journal of Immunology, Vol. 177, No. 10, 15.11.2006, p. 6730-6737.

Research output: Contribution to journalArticle

Zhang, X, Dong, HM, Lin, W, Voss, S, Hinkley, L, Westergren, M, Tian, G, Berry, D, Lewellen, D, Vile, RG, Chen, L, Farber, DL & Strome, SE 2006, 'Human bone marrow: A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function', Journal of Immunology, vol. 177, no. 10, pp. 6730-6737.
Zhang X, Dong HM, Lin W, Voss S, Hinkley L, Westergren M et al. Human bone marrow: A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function. Journal of Immunology. 2006 Nov 15;177(10):6730-6737.
Zhang, Xiaoyu ; Dong, Haidong M ; Lin, Wei ; Voss, Stephen ; Hinkley, Lucinda ; Westergren, Melissa ; Tian, Guoliang ; Berry, Daniel ; Lewellen, David ; Vile, Richard Geoffrey ; Chen, Lieping ; Farber, Donna L. ; Strome, Scott E. / Human bone marrow : A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function. In: Journal of Immunology. 2006 ; Vol. 177, No. 10. pp. 6730-6737.
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