TY - JOUR
T1 - Human bone marrow
T2 - A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function
AU - Zhang, Xiaoyu
AU - Dong, Haidong
AU - Lin, Wei
AU - Voss, Stephen
AU - Hinkley, Lucinda
AU - Westergren, Melissa
AU - Tian, Guoliang
AU - Berry, Daniel
AU - Lewellen, David
AU - Vile, Richard G.
AU - Chen, Lieping
AU - Farber, Donna L.
AU - Strome, Scott E.
PY - 2006/11/15
Y1 - 2006/11/15
N2 - The role of human bone marrow (BM) CD8+ T cells in the immune response to viral Ags is poorly defined. We report here the identification and characterization of a functionally enhanced effector memory CD8+ T cell population (TEM) in the BM of patients undergoing total joint replacement for osteoarthritis. These BM-derived TEM differ strikingly from correlate cells in peripheral blood (PB), expressing elevated levels of CD27, HLA-DR, CD38, CD69, and unique patterns of chemokine receptors. Interestingly, while BM TEM have low levels of resting perform and granzyme B, these molecules evidence profound up-regulation in response to TCR stimulation resulting in enhanced cytotoxic potential. Moreover, compared with the TEM subset in PB, BM CD8+ TEM cells demonstrate a more vigorous recall response to pooled viral Ags. Our results reveal that human BM serves as a repository for viral Ag-spccific TEM with great therapeutic potential in vaccine development.
AB - The role of human bone marrow (BM) CD8+ T cells in the immune response to viral Ags is poorly defined. We report here the identification and characterization of a functionally enhanced effector memory CD8+ T cell population (TEM) in the BM of patients undergoing total joint replacement for osteoarthritis. These BM-derived TEM differ strikingly from correlate cells in peripheral blood (PB), expressing elevated levels of CD27, HLA-DR, CD38, CD69, and unique patterns of chemokine receptors. Interestingly, while BM TEM have low levels of resting perform and granzyme B, these molecules evidence profound up-regulation in response to TCR stimulation resulting in enhanced cytotoxic potential. Moreover, compared with the TEM subset in PB, BM CD8+ TEM cells demonstrate a more vigorous recall response to pooled viral Ags. Our results reveal that human BM serves as a repository for viral Ag-spccific TEM with great therapeutic potential in vaccine development.
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U2 - 10.4049/jimmunol.177.10.6730
DO - 10.4049/jimmunol.177.10.6730
M3 - Article
C2 - 17082586
AN - SCOPUS:33750825269
SN - 0022-1767
VL - 177
SP - 6730
EP - 6737
JO - Journal of Immunology
JF - Journal of Immunology
IS - 10
ER -