TY - JOUR
T1 - Human β-herpesvirus interactions in solid organ transplant recipients
AU - Mendez, J. C.
AU - Dockrell, D. H.
AU - Espy, M. J.
AU - Smith, T. F.
AU - Wilson, J. A.
AU - Harmsen, W. S.
AU - Ilstrup, D.
AU - Paya, C. V.
PY - 2001/1/15
Y1 - 2001/1/15
N2 - The replication of β-herpesviruses - cytomegalovirus (CMV), human herpesvirus (HHV)-6, and HHV-7 - and their association with CMV disease and response to antiviral therapy were prospectively investigated in 33 liver transplant recipients not given antiviral prophylaxis. CMV, HHV-6, and HHV-7 DNA were detected within 8 weeks after transplantation in 70%, 33%, and 42% of the patients, respectively. The univariate association between CMV disease and the 3 β-herpesviruses was more significant by virus load quantitation than by qualitative detection of DNA. This association with high levels of CMV, HHV-6, and HHV-7 (P < .001, .022, and .001, respectively) occurred mainly in CMV-seronegative recipients of transplants from CMV-seropositive donors. Antiviral therapy with ganciclovir (Gcv) reduced the load of CMV and HHV-6 and HHV-7. These results suggest that CMV disease in transplant recipients is related to the unique interaction of the 3 β-herpesviruses and is ultimately reduced after intravenous Gcv treatment.
AB - The replication of β-herpesviruses - cytomegalovirus (CMV), human herpesvirus (HHV)-6, and HHV-7 - and their association with CMV disease and response to antiviral therapy were prospectively investigated in 33 liver transplant recipients not given antiviral prophylaxis. CMV, HHV-6, and HHV-7 DNA were detected within 8 weeks after transplantation in 70%, 33%, and 42% of the patients, respectively. The univariate association between CMV disease and the 3 β-herpesviruses was more significant by virus load quantitation than by qualitative detection of DNA. This association with high levels of CMV, HHV-6, and HHV-7 (P < .001, .022, and .001, respectively) occurred mainly in CMV-seronegative recipients of transplants from CMV-seropositive donors. Antiviral therapy with ganciclovir (Gcv) reduced the load of CMV and HHV-6 and HHV-7. These results suggest that CMV disease in transplant recipients is related to the unique interaction of the 3 β-herpesviruses and is ultimately reduced after intravenous Gcv treatment.
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U2 - 10.1086/317929
DO - 10.1086/317929
M3 - Article
C2 - 11120923
AN - SCOPUS:0035863361
SN - 0022-1899
VL - 183
SP - 179
EP - 184
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -