HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer

Vincenzo Catalano; Pasquale Mellone; Alfredo d'Avino; Viji Shridhar; Maria Pia Staccioli; Francesco Graziano; Paolo Giordani; David Rossi; Anna Maria Baldelli; Paolo Alessandroni; Daniele Santini; Laura Lorenzon; Enrica Testa; Silvia D'Emidio; Michele De Nictolis; Pietro Muretto; Stefano Luzi Fedeli; Alfonso Baldi

doi:10.1111/j.1365-2559.2011.03818.x

HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer

Vincenzo Catalano, Pasquale Mellone, Alfredo d'Avino, Viji Shridhar, Maria Pia Staccioli, Francesco Graziano, Paolo Giordani, David Rossi, Anna Maria Baldelli, Paolo Alessandroni, Daniele Santini, Laura Lorenzon, Enrica Testa, Silvia D'Emidio, Michele De Nictolis, Pietro Muretto, Stefano Luzi Fedeli, Alfonso Baldi

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Aims: HtrA1 is a member of the HtrA (high-temperature requirement factor A) family of serine proteases. HtrA1 plays a protective role in various malignancies due to its tumour suppressive properties. The aim of this study was to determine HtrA1 expression as a predictor of chemoresponse in patients with advanced gastric cancer. Methods and results: HtrA1 expression was determined by immunohistochemistry on specimens of primary gastric cancer from 80 patients treated consecutively with cisplatin-based combination chemotherapy. Response to chemotherapy was assessed according to Response Evaluation Criteria in Solid Tumours (RECIST) criteria. Our population consisted of males/females [51/29; median age 64years (range 32-82)]. A complete or partial response was observed in 71.4% [95% confidence interval (CI) 54.7-88.2], 66.7% (95% CI 47.8-85.5) and 28.6% (95 CI 11.8-45.3) of tumours showing high, medium and low HtrA1 expression, respectively. A statistically significant association between HtrA1 expression and the clinical response was observed (P=0.002). The median overall survival for patients with high/medium expression was 17months compared to 9.5months for patients with low HtrA1 expression (P=0.037). Conclusions: Identification of HtrA1 in gastric cancer prior to chemotherapy indicates that levels of HtrA1 could be used to predict response to platinum-based combination therapies. Further assessment of HtrA1 expression is highly warranted in large, prospective studies.

Original language	English (US)
Pages (from-to)	669-678
Number of pages	10
Journal	Histopathology
Volume	58
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2559.2011.03818.x
State	Published - Apr 2011

Keywords

Chemoresistance
Chemotherapy
Cisplatin
Gastric cancer
HtrA1

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

Access to Document

10.1111/j.1365-2559.2011.03818.x

Cite this

Catalano, V., Mellone, P., d'Avino, A., Shridhar, V., Staccioli, M. P., Graziano, F., Giordani, P., Rossi, D., Baldelli, A. M., Alessandroni, P., Santini, D., Lorenzon, L., Testa, E., D'Emidio, S., De Nictolis, M., Muretto, P., Fedeli, S. L., & Baldi, A. (2011). HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer. Histopathology, 58(5), 669-678. https://doi.org/10.1111/j.1365-2559.2011.03818.x

Catalano, V, Mellone, P, d'Avino, A, Shridhar, V, Staccioli, MP, Graziano, F, Giordani, P, Rossi, D, Baldelli, AM, Alessandroni, P, Santini, D, Lorenzon, L, Testa, E, D'Emidio, S, De Nictolis, M, Muretto, P, Fedeli, SL & Baldi, A 2011, 'HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer', Histopathology, vol. 58, no. 5, pp. 669-678. https://doi.org/10.1111/j.1365-2559.2011.03818.x

@article{2466235c63464d779673f68b4aadc49a,

title = "HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer",

abstract = "Aims: HtrA1 is a member of the HtrA (high-temperature requirement factor A) family of serine proteases. HtrA1 plays a protective role in various malignancies due to its tumour suppressive properties. The aim of this study was to determine HtrA1 expression as a predictor of chemoresponse in patients with advanced gastric cancer. Methods and results: HtrA1 expression was determined by immunohistochemistry on specimens of primary gastric cancer from 80 patients treated consecutively with cisplatin-based combination chemotherapy. Response to chemotherapy was assessed according to Response Evaluation Criteria in Solid Tumours (RECIST) criteria. Our population consisted of males/females [51/29; median age 64years (range 32-82)]. A complete or partial response was observed in 71.4% [95% confidence interval (CI) 54.7-88.2], 66.7% (95% CI 47.8-85.5) and 28.6% (95 CI 11.8-45.3) of tumours showing high, medium and low HtrA1 expression, respectively. A statistically significant association between HtrA1 expression and the clinical response was observed (P=0.002). The median overall survival for patients with high/medium expression was 17months compared to 9.5months for patients with low HtrA1 expression (P=0.037). Conclusions: Identification of HtrA1 in gastric cancer prior to chemotherapy indicates that levels of HtrA1 could be used to predict response to platinum-based combination therapies. Further assessment of HtrA1 expression is highly warranted in large, prospective studies.",

keywords = "Chemoresistance, Chemotherapy, Cisplatin, Gastric cancer, HtrA1",

author = "Vincenzo Catalano and Pasquale Mellone and Alfredo d'Avino and Viji Shridhar and Staccioli, {Maria Pia} and Francesco Graziano and Paolo Giordani and David Rossi and Baldelli, {Anna Maria} and Paolo Alessandroni and Daniele Santini and Laura Lorenzon and Enrica Testa and Silvia D'Emidio and {De Nictolis}, Michele and Pietro Muretto and Fedeli, {Stefano Luzi} and Alfonso Baldi",

year = "2011",

month = apr,

doi = "10.1111/j.1365-2559.2011.03818.x",

language = "English (US)",

volume = "58",

pages = "669--678",

journal = "Histopathology",

issn = "0309-0167",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer

AU - Catalano, Vincenzo

AU - Mellone, Pasquale

AU - d'Avino, Alfredo

AU - Shridhar, Viji

AU - Staccioli, Maria Pia

AU - Graziano, Francesco

AU - Giordani, Paolo

AU - Rossi, David

AU - Baldelli, Anna Maria

AU - Alessandroni, Paolo

AU - Santini, Daniele

AU - Lorenzon, Laura

AU - Testa, Enrica

AU - D'Emidio, Silvia

AU - De Nictolis, Michele

AU - Muretto, Pietro

AU - Fedeli, Stefano Luzi

AU - Baldi, Alfonso

PY - 2011/4

Y1 - 2011/4

N2 - Aims: HtrA1 is a member of the HtrA (high-temperature requirement factor A) family of serine proteases. HtrA1 plays a protective role in various malignancies due to its tumour suppressive properties. The aim of this study was to determine HtrA1 expression as a predictor of chemoresponse in patients with advanced gastric cancer. Methods and results: HtrA1 expression was determined by immunohistochemistry on specimens of primary gastric cancer from 80 patients treated consecutively with cisplatin-based combination chemotherapy. Response to chemotherapy was assessed according to Response Evaluation Criteria in Solid Tumours (RECIST) criteria. Our population consisted of males/females [51/29; median age 64years (range 32-82)]. A complete or partial response was observed in 71.4% [95% confidence interval (CI) 54.7-88.2], 66.7% (95% CI 47.8-85.5) and 28.6% (95 CI 11.8-45.3) of tumours showing high, medium and low HtrA1 expression, respectively. A statistically significant association between HtrA1 expression and the clinical response was observed (P=0.002). The median overall survival for patients with high/medium expression was 17months compared to 9.5months for patients with low HtrA1 expression (P=0.037). Conclusions: Identification of HtrA1 in gastric cancer prior to chemotherapy indicates that levels of HtrA1 could be used to predict response to platinum-based combination therapies. Further assessment of HtrA1 expression is highly warranted in large, prospective studies.

AB - Aims: HtrA1 is a member of the HtrA (high-temperature requirement factor A) family of serine proteases. HtrA1 plays a protective role in various malignancies due to its tumour suppressive properties. The aim of this study was to determine HtrA1 expression as a predictor of chemoresponse in patients with advanced gastric cancer. Methods and results: HtrA1 expression was determined by immunohistochemistry on specimens of primary gastric cancer from 80 patients treated consecutively with cisplatin-based combination chemotherapy. Response to chemotherapy was assessed according to Response Evaluation Criteria in Solid Tumours (RECIST) criteria. Our population consisted of males/females [51/29; median age 64years (range 32-82)]. A complete or partial response was observed in 71.4% [95% confidence interval (CI) 54.7-88.2], 66.7% (95% CI 47.8-85.5) and 28.6% (95 CI 11.8-45.3) of tumours showing high, medium and low HtrA1 expression, respectively. A statistically significant association between HtrA1 expression and the clinical response was observed (P=0.002). The median overall survival for patients with high/medium expression was 17months compared to 9.5months for patients with low HtrA1 expression (P=0.037). Conclusions: Identification of HtrA1 in gastric cancer prior to chemotherapy indicates that levels of HtrA1 could be used to predict response to platinum-based combination therapies. Further assessment of HtrA1 expression is highly warranted in large, prospective studies.

KW - Chemoresistance

KW - Chemotherapy

KW - Cisplatin

KW - Gastric cancer

KW - HtrA1

UR - http://www.scopus.com/inward/record.url?scp=79954591707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954591707&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2559.2011.03818.x

DO - 10.1111/j.1365-2559.2011.03818.x

M3 - Article

C2 - 21447133

AN - SCOPUS:79954591707

SN - 0309-0167

VL - 58

SP - 669

EP - 678

JO - Histopathology

JF - Histopathology

IS - 5

ER -

HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this