Abstract
Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-129 |
| Number of pages | 9 |
| Journal | Annals of Medicine |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2005 |
| Externally published | Yes |
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Keywords
- 5-hydroxytryptamine (serotonin) receptor 2A
- 5HT2A
- Association
- HTR2A
- Neuropsychiatric
- Serotonin 5-HT-2 receptor
ASJC Scopus subject areas
- Medicine(all)
Cite this
HTR2A : Association and expression studies in neuropsychiatric genetics. / Norton, Nadine; Owen, Michael J.
In: Annals of Medicine, Vol. 37, No. 2, 2005, p. 121-129.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - HTR2A
T2 - Association and expression studies in neuropsychiatric genetics
AU - Norton, Nadine
AU - Owen, Michael J.
PY - 2005
Y1 - 2005
N2 - Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.
AB - Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.
KW - 5-hydroxytryptamine (serotonin) receptor 2A
KW - 5HT2A
KW - Association
KW - HTR2A
KW - Neuropsychiatric
KW - Serotonin 5-HT-2 receptor
UR - http://www.scopus.com/inward/record.url?scp=17844377615&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17844377615&partnerID=8YFLogxK
U2 - 10.1080/07853890510037347
DO - 10.1080/07853890510037347
M3 - Review article
C2 - 16026119
AN - SCOPUS:17844377615
VL - 37
SP - 121
EP - 129
JO - Annals of Medicine
JF - Annals of Medicine
SN - 0785-3890
IS - 2
ER -