HTR2A: Association and expression studies in neuropsychiatric genetics

Nadine Norton, Michael J. Owen

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalAnnals of Medicine
Volume37
Issue number2
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Serotonin Receptors
Phenotype
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity
Anxiety Disorders
Mood Disorders
Suicide
Schizophrenia
Alzheimer Disease
Messenger RNA
Genes
Proteins
Feeding and Eating Disorders

Keywords

  • 5-hydroxytryptamine (serotonin) receptor 2A
  • 5HT2A
  • Association
  • HTR2A
  • Neuropsychiatric
  • Serotonin 5-HT-2 receptor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

HTR2A : Association and expression studies in neuropsychiatric genetics. / Norton, Nadine; Owen, Michael J.

In: Annals of Medicine, Vol. 37, No. 2, 2005, p. 121-129.

Research output: Contribution to journalReview article

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