Abstract
Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-129 |
| Number of pages | 9 |
| Journal | Annals of Medicine |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2005 |
Keywords
- 5-hydroxytryptamine (serotonin) receptor 2A
- 5HT2A
- Association
- HTR2A
- Neuropsychiatric
- Serotonin 5-HT-2 receptor
ASJC Scopus subject areas
- Medicine(all)
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Cite this
Norton, N., & Owen, M. J. (2005). HTR2A: Association and expression studies in neuropsychiatric genetics. Annals of Medicine, 37(2), 121-129. https://doi.org/10.1080/07853890510037347