HTR2A: Association and expression studies in neuropsychiatric genetics

Nadine Norton, Michael J. Owen

Research output: Contribution to journalReview article

76 Scopus citations

Abstract

Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalAnnals of Medicine
Volume37
Issue number2
DOIs
StatePublished - May 11 2005

    Fingerprint

Keywords

  • 5-hydroxytryptamine (serotonin) receptor 2A
  • 5HT2A
  • Association
  • HTR2A
  • Neuropsychiatric
  • Serotonin 5-HT-2 receptor

ASJC Scopus subject areas

  • Medicine(all)

Cite this