HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis

S. A. Quadri, Veena D Taneja, N. K. Mehra, D. P. Singal

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The distribution of HSP70-1 promoter alleles was studied in 90 adult Caucasian RA patients (65 European and 25 Asian Indian) and 113 normal controls (60 European and 53 Asian Indian). The HSP70-1 promoter alleles were defined by oligonucleotide typing of polymerase chain (PCR)-amplified genomic DNA. The prevalence of HSP70-1 promoter allele "B" was significantly (p<0.0004, pc<0.0012; RR=5.1) higher in RA patients (22.2%) compared to normal controls (5.3%). It is likely therefore that HSP70-1 promoter allele B is associated with susceptibility to RA.

Original languageEnglish (US)
Pages (from-to)183-185
Number of pages3
JournalClinical and Experimental Rheumatology
Volume14
Issue number2
StatePublished - Mar 1996
Externally publishedYes

Fingerprint

Genetic Promoter Regions
Rheumatoid Arthritis
Alleles
Polymerase Chain Reaction
DNA

Keywords

  • Extended haplotypes
  • HLA
  • HSP70-1 promoter
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis. / Quadri, S. A.; Taneja, Veena D; Mehra, N. K.; Singal, D. P.

In: Clinical and Experimental Rheumatology, Vol. 14, No. 2, 03.1996, p. 183-185.

Research output: Contribution to journalArticle

Quadri, S. A. ; Taneja, Veena D ; Mehra, N. K. ; Singal, D. P. / HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis. In: Clinical and Experimental Rheumatology. 1996 ; Vol. 14, No. 2. pp. 183-185.
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