HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis

S. A. Quadri, V. Taneja, N. K. Mehra, D. P. Singal

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The distribution of HSP70-1 promoter alleles was studied in 90 adult Caucasian RA patients (65 European and 25 Asian Indian) and 113 normal controls (60 European and 53 Asian Indian). The HSP70-1 promoter alleles were defined by oligonucleotide typing of polymerase chain (PCR)-amplified genomic DNA. The prevalence of HSP70-1 promoter allele "B" was significantly (p<0.0004, pc<0.0012; RR=5.1) higher in RA patients (22.2%) compared to normal controls (5.3%). It is likely therefore that HSP70-1 promoter allele B is associated with susceptibility to RA.

Original languageEnglish (US)
Pages (from-to)183-185
Number of pages3
JournalClinical and experimental rheumatology
Volume14
Issue number2
StatePublished - Mar 1 1996

Keywords

  • Extended haplotypes
  • HLA
  • HSP70-1 promoter
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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