How to record high-frequency oscillations in epilepsy: A practical guideline

Maeike Zijlmans, Gregory Alan Worrell, Matthias Dümpelmann, Thomas Stieglitz, Andrea Barborica, Marcel Heers, Akio Ikeda, Naotaka Usui, Michel Le Van Quyen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: Technology for localizing epileptogenic brain regions plays a central role in surgical planning. Recent improvements in acquisition and electrode technology have revealed that high-frequency oscillations (HFOs) within the 80-500 Hz frequency range provide the neurophysiologist with new information about the extent of the epileptogenic tissue in addition to ictal and interictal lower frequency events. Nevertheless, two decades after their discovery there remain questions about HFOs as biomarkers of epileptogenic brain and there use in clinical practice. Methods: In this review, we provide practical, technical guidance for epileptologists and clinical researchers on recording, evaluation, and interpretation of ripples, fast ripples, and very high-frequency oscillations. Results: We emphasize the importance of low noise recording to minimize artifacts. HFO analysis, either visual or with automatic detection methods, of high fidelity recordings can still be challenging because of various artifacts including muscle, movement, and filtering. Magnetoencephalography and intracranial electroencephalography (iEEG) recordings are subject to the same artifacts. Significance: High-frequency oscillations are promising new biomarkers in epilepsy. This review provides interested researchers and clinicians with a review of current state of the art of recording and identification and potential challenges to clinical translation.

Original languageEnglish (US)
JournalEpilepsia
DOIs
StateAccepted/In press - 2017

Fingerprint

Artifacts
Epilepsy
Guidelines
Biomarkers
Research Personnel
Technology
Magnetoencephalography
Brain
Noise
Electrodes
Stroke
Muscles
Electrocorticography

Keywords

  • EEG
  • High-frequency oscillations (HFOs)
  • Magnetoencephalography
  • pHFOs
  • Ripples

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Zijlmans, M., Worrell, G. A., Dümpelmann, M., Stieglitz, T., Barborica, A., Heers, M., ... Le Van Quyen, M. (Accepted/In press). How to record high-frequency oscillations in epilepsy: A practical guideline. Epilepsia. https://doi.org/10.1111/epi.13814

How to record high-frequency oscillations in epilepsy : A practical guideline. / Zijlmans, Maeike; Worrell, Gregory Alan; Dümpelmann, Matthias; Stieglitz, Thomas; Barborica, Andrea; Heers, Marcel; Ikeda, Akio; Usui, Naotaka; Le Van Quyen, Michel.

In: Epilepsia, 2017.

Research output: Contribution to journalArticle

Zijlmans, M, Worrell, GA, Dümpelmann, M, Stieglitz, T, Barborica, A, Heers, M, Ikeda, A, Usui, N & Le Van Quyen, M 2017, 'How to record high-frequency oscillations in epilepsy: A practical guideline', Epilepsia. https://doi.org/10.1111/epi.13814
Zijlmans, Maeike ; Worrell, Gregory Alan ; Dümpelmann, Matthias ; Stieglitz, Thomas ; Barborica, Andrea ; Heers, Marcel ; Ikeda, Akio ; Usui, Naotaka ; Le Van Quyen, Michel. / How to record high-frequency oscillations in epilepsy : A practical guideline. In: Epilepsia. 2017.
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