How to Do Genetic and Molecular Epidemiologic Research

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epidemiology is an established field that studies the distribution of disease in populations, and evaluates the effects of disease determinants in attenuating disease presentation and natural history. Compared to traditional epidemiology, genetic and molecular epidemiology are relatively young fields that have evolved with recent advances in genetics and molecular biology, and represent the union of several disciplines including laboratory science, biostatistics, and epidemiology. Genetic epidemiology focuses on the study of genetic variants, and their role in disease in the context of environmental factors. Molecular epidemiology studies molecular processes, and how variations in biochemical and cellular processes can impact disease etiology and presentation. As both fields can study the contribution of genetic and environmental risk factors to the development and distribution of disease across families and populations, there is overlap between the two. Importantly, epidemiologic methods can be extremely useful in translating laboratory observations into a better understanding of disease pathophysiology. In this chapter, a brief summary of the fields will be provided, followed by an overview of study designs related to these fields to provide a resource for those wishing to learn more about them when applied to gastrointestinal disease. This edition first published 2014

Original languageEnglish (US)
Title of host publicationGI Epidemiology: Diseases and Clinical Methodology: Second Edition
PublisherWiley Blackwell
Pages98-105
Number of pages8
ISBN (Electronic)9781118727072
ISBN (Print)9780470672570
DOIs
StatePublished - Jan 13 2014

Fingerprint

Molecular Biology
Molecular Epidemiology
Research
Epidemiology
Biochemical Phenomena
Biostatistics
Epidemiologic Methods
Gastrointestinal Diseases
Natural History
Population

Keywords

  • Biomarkers
  • Genetic epidemiology
  • Genetics
  • Molecular epidemiology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Saito Loftus, Y. A. (2014). How to Do Genetic and Molecular Epidemiologic Research. In GI Epidemiology: Diseases and Clinical Methodology: Second Edition (pp. 98-105). Wiley Blackwell. https://doi.org/10.1002/9781118727072.ch10

How to Do Genetic and Molecular Epidemiologic Research. / Saito Loftus, Yuri Ann.

GI Epidemiology: Diseases and Clinical Methodology: Second Edition. Wiley Blackwell, 2014. p. 98-105.

Research output: Chapter in Book/Report/Conference proceedingChapter

Saito Loftus, YA 2014, How to Do Genetic and Molecular Epidemiologic Research. in GI Epidemiology: Diseases and Clinical Methodology: Second Edition. Wiley Blackwell, pp. 98-105. https://doi.org/10.1002/9781118727072.ch10
Saito Loftus YA. How to Do Genetic and Molecular Epidemiologic Research. In GI Epidemiology: Diseases and Clinical Methodology: Second Edition. Wiley Blackwell. 2014. p. 98-105 https://doi.org/10.1002/9781118727072.ch10
Saito Loftus, Yuri Ann. / How to Do Genetic and Molecular Epidemiologic Research. GI Epidemiology: Diseases and Clinical Methodology: Second Edition. Wiley Blackwell, 2014. pp. 98-105
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