How Do Different Indices of Hepatic Enhancement with Gadoxetic Acid Compare in Predicting Liver Failure and Other Major Complications after Hepatectomy?

Andreu F. Costa, Amélie Tremblay St-Germain, Mohamed Abdolell, Rory L. Smoot, Sean Cleary, Kartik S. Jhaveri

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Objective The objective of this study was to assess the accuracy of gadoxetic acid hepatic enhancement indices in predicting posthepatectomy liver failure (PHLF) and other major complications (OMCs). Methods Sixty-five patients underwent prehepatectomy gadoxetic acid-enhanced magnetic resonance imaging. Enhancement indices were calculated by obtaining regions of interest on magnetic resonance images and segmented volumes of the liver and spleen. Multivariate regression analysis was performed to predict PHLF and OMC as a function of the indices, and areas under the receiver operator characteristic (AUROC) curves were calculated. Results Areas under the receiver operator characteristic values varied from 0.412 to 0.681 and 0.462 to 0.738 in predicting PHLF and OMC, respectively. The most accurate indices in predicting PHLF were the region of interest-based, fat-normalized relative liver enhancement and liver enhancement index (AUROC, 0.681). The most accurate index in predicting OMC was the volumetric least-squares regression slope of a pharmacokinetic model (Khep-V, AUROC, 0.738). Conclusions Indices of gadoxetic acid liver enhancement demonstrate variable performance in predicting PHLF and OMC.

Original languageEnglish (US)
Pages (from-to)380-386
Number of pages7
JournalJournal of Computer Assisted Tomography
Issue number3
StatePublished - May 1 2018



  • gadoxetic acid (Gd-EOB DTPA)
  • hepatectomy
  • liver function
  • posthepatectomy liver failure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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