How do cells sense a transcellular pressure difference?

a combined computational and experimental approach

Anna McVittie, Daniel J Tschumperlin, Jeffery Drazen, Roger Kamm

Research output: Contribution to journalArticle

Abstract

Mitogen activated protein (MAP) kinases were activated by a number of stimuli. Among the three known MAP kinase family members, extracellular signal-related kinase (ERK) was strongly activated in the transepithelial pressure system after one minute (30cmH20), with the response peaking at five minutes. Little or no response was seen in the p38 or c-jun N terminal MAP kinases.

Original languageEnglish (US)
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - 2000
Externally publishedYes

Fingerprint

Proteins

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

How do cells sense a transcellular pressure difference? a combined computational and experimental approach. / McVittie, Anna; Tschumperlin, Daniel J; Drazen, Jeffery; Kamm, Roger.

In: Annals of Biomedical Engineering, Vol. 28, No. SUPPL. 1, 2000.

Research output: Contribution to journalArticle

@article{c136047e2ebb4f7cba527dcac5cc504c,
title = "How do cells sense a transcellular pressure difference?: a combined computational and experimental approach",
abstract = "Mitogen activated protein (MAP) kinases were activated by a number of stimuli. Among the three known MAP kinase family members, extracellular signal-related kinase (ERK) was strongly activated in the transepithelial pressure system after one minute (30cmH20), with the response peaking at five minutes. Little or no response was seen in the p38 or c-jun N terminal MAP kinases.",
author = "Anna McVittie and Tschumperlin, {Daniel J} and Jeffery Drazen and Roger Kamm",
year = "2000",
language = "English (US)",
volume = "28",
journal = "Annals of Biomedical Engineering",
issn = "0090-6964",
publisher = "Springer Netherlands",
number = "SUPPL. 1",

}

TY - JOUR

T1 - How do cells sense a transcellular pressure difference?

T2 - a combined computational and experimental approach

AU - McVittie, Anna

AU - Tschumperlin, Daniel J

AU - Drazen, Jeffery

AU - Kamm, Roger

PY - 2000

Y1 - 2000

N2 - Mitogen activated protein (MAP) kinases were activated by a number of stimuli. Among the three known MAP kinase family members, extracellular signal-related kinase (ERK) was strongly activated in the transepithelial pressure system after one minute (30cmH20), with the response peaking at five minutes. Little or no response was seen in the p38 or c-jun N terminal MAP kinases.

AB - Mitogen activated protein (MAP) kinases were activated by a number of stimuli. Among the three known MAP kinase family members, extracellular signal-related kinase (ERK) was strongly activated in the transepithelial pressure system after one minute (30cmH20), with the response peaking at five minutes. Little or no response was seen in the p38 or c-jun N terminal MAP kinases.

UR - http://www.scopus.com/inward/record.url?scp=0034499991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034499991&partnerID=8YFLogxK

M3 - Article

VL - 28

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

SN - 0090-6964

IS - SUPPL. 1

ER -