Host genetics in follicular lymphoma

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

The role of inherited (host) genetic susceptibility in the pathogenesis of follicular lymphoma (FL) is reviewed. First degree relatives of FL patients are at an increased risk of FL, suggesting a role for inherited factors. While there have been no linkage studies in FL families, candidate gene and genome-wide association studies have identified several risk loci which have been confirmed in independent studies. These include regions on 6p21.32-33 and TNF family members. Host genetics has also been hypothesized to influence treatment response, disease progression and overall survival. Early leads in FL prognosis include pathways that regulate immune function, antibody-dependent cellular cytotoxicity, chemotaxis, and one-carbon metabolism, although few of these associations have been independently confirmed. While the use of host genetics to identify individuals at high risk of FL or to predict FL treatment response and prognosis appears to be very promising, it is not yet ready for the clinic.

Original languageEnglish (US)
Pages (from-to)121-134
Number of pages14
JournalBest Practice and Research: Clinical Haematology
Volume24
Issue number2
DOIs
StatePublished - Jun 2011

Keywords

  • follicular lymphoma
  • genetics
  • prognosis
  • risk
  • single nucleotide polymorphisms

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Host genetics in follicular lymphoma'. Together they form a unique fingerprint.

  • Cite this