TY - JOUR
T1 - Host and graft thickness after descemet stripping endothelial keratoplasty for fuchs endothelial dystrophy
AU - Ahmed, Kamran A.
AU - McLaren, Jay W.
AU - Baratz, Keith H.
AU - Maguire, Leo J.
AU - Kittleson, Katrina M.
AU - Patel, Sanjay V.
N1 - Funding Information:
Publication of this article was supported by an Unrestricted Grant to the Department of Ophthalmology and Dr Patel as Olga Keith Wiess Special Scholar from Research to Prevent Blindness , New York, New York; and the Mayo Foundation , Rochester, Minnesota. The authors indicate no financial conflict of interest. Involved in Design of study (J.W.M., K.H.B., L.J.M., S.V.P.); Conduct of study (K.A.A., J.W.M., K.H.B., L.J.M., K.M.K., S.V.P.); Collection (K.A.A., K.H.B., L.J.M., K.M.K., S.V.P.), management (K.A.A., J.W.M., K.M.K., S.V.P.), analysis (K.A.A., J.W.M., K.M.K., S.V.P.), and interpretation (K.A.A., J.W.M., K.H.B., L.J.M., S.V.P.) of data; and Preparation (K.A.A., J.W.M., S.V.P.), review (K.A.A., J.W.M., K.H.B., L.J.M., K.M.K., S.V.P.), and approval (K.A.A., J.W.M., K.H.B., L.J.M., K.M.K., S.V.P.) of the manuscript. This study was approved by the Mayo Clinic Institutional Review Board and complied with the Health Insurance Portability and Accountability Act. Informed consent was obtained from all subjects.
PY - 2010/10
Y1 - 2010/10
N2 - Purpose: To determine relationships between vision, forward scatter, and total corneal and graft thicknesses after Descemet stripping endothelial keratoplasty (DSEK). Design: Prospective, cohort study. Methods: Forty-four eyes with Fuchs endothelial dystrophy were examined before and at 1, 3, 6, and 12 months after DSEK; all eyes were pseudophakic after surgery. Central total corneal and graft thicknesses were measured using confocal microscopy. Best-corrected high-contrast visual acuity (BCVA) was measured using the electronic Early Treatment Diabetic Retinopathy Study protocol, and forward light scatter was measured using a straylight meter. Results: Total corneal thickness was 610 ± 50 μm (mean ± standard deviation) before DSEK, increased to 680 ± 74 μm by 1 month after DSEK (P < .001), and stabilized at 660 ± 68 μm by 3 months after DSEK (P = .03 vs 1 month). Graft thickness was 170 ± 57 μm at 1 month, decreased to 157 ± 49 μm by 3 months (P = .004), and then remained stable through 12 months (156 ± 51 μm; P = .99 vs 3 months). BCVA was 0.44 ± 0.21 logarithm of the minimal angle of resolution (logMAR) units (Snellen equivalent, 20/55) before DSEK, improved to 0.26 ± 0.20 logMAR units (Snellen equivalent, 20/36) by 3 months (P < .001), and improved to 0.16 ± 0.16 logMAR units (Snellen equivalent, 20/29) at 12 months (P < .001 vs 3 months). BCVA and forward light scatter did not correlate with corneal or graft thickness after DSEK. Conclusions: Stromal edema resolves by 3 months after DSEK for Fuchs dystrophy, whereas visual acuity continues to improve through 12 months. Thicker corneas and grafts are not associated with worse visual acuity or increased forward scatter.
AB - Purpose: To determine relationships between vision, forward scatter, and total corneal and graft thicknesses after Descemet stripping endothelial keratoplasty (DSEK). Design: Prospective, cohort study. Methods: Forty-four eyes with Fuchs endothelial dystrophy were examined before and at 1, 3, 6, and 12 months after DSEK; all eyes were pseudophakic after surgery. Central total corneal and graft thicknesses were measured using confocal microscopy. Best-corrected high-contrast visual acuity (BCVA) was measured using the electronic Early Treatment Diabetic Retinopathy Study protocol, and forward light scatter was measured using a straylight meter. Results: Total corneal thickness was 610 ± 50 μm (mean ± standard deviation) before DSEK, increased to 680 ± 74 μm by 1 month after DSEK (P < .001), and stabilized at 660 ± 68 μm by 3 months after DSEK (P = .03 vs 1 month). Graft thickness was 170 ± 57 μm at 1 month, decreased to 157 ± 49 μm by 3 months (P = .004), and then remained stable through 12 months (156 ± 51 μm; P = .99 vs 3 months). BCVA was 0.44 ± 0.21 logarithm of the minimal angle of resolution (logMAR) units (Snellen equivalent, 20/55) before DSEK, improved to 0.26 ± 0.20 logMAR units (Snellen equivalent, 20/36) by 3 months (P < .001), and improved to 0.16 ± 0.16 logMAR units (Snellen equivalent, 20/29) at 12 months (P < .001 vs 3 months). BCVA and forward light scatter did not correlate with corneal or graft thickness after DSEK. Conclusions: Stromal edema resolves by 3 months after DSEK for Fuchs dystrophy, whereas visual acuity continues to improve through 12 months. Thicker corneas and grafts are not associated with worse visual acuity or increased forward scatter.
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U2 - 10.1016/j.ajo.2010.05.011
DO - 10.1016/j.ajo.2010.05.011
M3 - Article
C2 - 20688317
AN - SCOPUS:77957273179
SN - 0002-9394
VL - 150
SP - 490-497.e1-e2
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 4
ER -