Hormone Receptor Expression in Renal Angiomyolipoma

Clinicopathologic Correlation

Stephen A. Boorjian, Yuri Sheinin, Paul L. Crispen, Christine M. Lohse, Eugene D Kwon, Bradley C. Leibovich

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objectives: Although renal angiomyolipoma (AML) occurs more commonly in females than males, the origin of this difference in incidence by sex is unknown. Therefore, we investigated the expression of the androgen receptor (AR), estrogen receptor subtypes alpha (ERα) and beta (ERβ), progesterone receptor, and the enzyme aromatase in renal AML. Methods: We evaluated specimens from 110 patients who had undergone resection of a renal AML, including 90 women and 20 men. Immunohistochemistry was performed using monoclonal antibodies on paraffin-embedded tissue sections. Expression was correlated with patient demographics and tumor pathologic features. Results: ERβ was expressed in 100% (106 of 106) of the AML specimens evaluated. Of the 104 specimens that could be assessed for the AR, 82 (79%) demonstrated staining. Of 110 lesions, 31 (28%), 42 (38%), and 11 (10%) expressed ERα, progesterone receptor, and aromatase, respectively. The level of ERβ expression was not associated with patient age (P = 0.92), sex (P = 0.82), a diagnosis of tuberous sclerosis (P = 0.56), or histologic subtype of AML (P = 0.94). A trend was found toward increased AR expression in men (P = 0.069) and younger patients (P = 0.052), and ERα was expressed in the AML specimens from 5 (71%) of 7 patients with tuberous sclerosis compared with 26 (25%) of 103 without tuberous sclerosis (P = 0.018). Both AR and ERα expression were more common in the triphasic subtype of AML than in the lipomatous tumors (P = 0.046 for both). Conclusions: The results of our study have shown that ERβ expression is ubiquitous in renal AML, and the AR is found in most tumors. ERα and progesterone receptor were expressed in approximately one third of cases. These data suggest a potential role for hormones in the pathogenesis and management of renal AML.

Original languageEnglish (US)
Pages (from-to)927-932
Number of pages6
JournalUrology
Volume72
Issue number4
DOIs
StatePublished - Oct 2008

Fingerprint

Angiomyolipoma
Hormones
Kidney
Androgen Receptors
Tuberous Sclerosis
Progesterone Receptors
Aromatase
Neoplasms
Estrogen Receptor alpha
Paraffin
Immunohistochemistry
Monoclonal Antibodies
Demography
Staining and Labeling

ASJC Scopus subject areas

  • Urology

Cite this

Boorjian, S. A., Sheinin, Y., Crispen, P. L., Lohse, C. M., Kwon, E. D., & Leibovich, B. C. (2008). Hormone Receptor Expression in Renal Angiomyolipoma: Clinicopathologic Correlation. Urology, 72(4), 927-932. https://doi.org/10.1016/j.urology.2008.01.067

Hormone Receptor Expression in Renal Angiomyolipoma : Clinicopathologic Correlation. / Boorjian, Stephen A.; Sheinin, Yuri; Crispen, Paul L.; Lohse, Christine M.; Kwon, Eugene D; Leibovich, Bradley C.

In: Urology, Vol. 72, No. 4, 10.2008, p. 927-932.

Research output: Contribution to journalArticle

Boorjian, SA, Sheinin, Y, Crispen, PL, Lohse, CM, Kwon, ED & Leibovich, BC 2008, 'Hormone Receptor Expression in Renal Angiomyolipoma: Clinicopathologic Correlation', Urology, vol. 72, no. 4, pp. 927-932. https://doi.org/10.1016/j.urology.2008.01.067
Boorjian, Stephen A. ; Sheinin, Yuri ; Crispen, Paul L. ; Lohse, Christine M. ; Kwon, Eugene D ; Leibovich, Bradley C. / Hormone Receptor Expression in Renal Angiomyolipoma : Clinicopathologic Correlation. In: Urology. 2008 ; Vol. 72, No. 4. pp. 927-932.
@article{dad4a4c256ee43eb896421842eeaf4a4,
title = "Hormone Receptor Expression in Renal Angiomyolipoma: Clinicopathologic Correlation",
abstract = "Objectives: Although renal angiomyolipoma (AML) occurs more commonly in females than males, the origin of this difference in incidence by sex is unknown. Therefore, we investigated the expression of the androgen receptor (AR), estrogen receptor subtypes alpha (ERα) and beta (ERβ), progesterone receptor, and the enzyme aromatase in renal AML. Methods: We evaluated specimens from 110 patients who had undergone resection of a renal AML, including 90 women and 20 men. Immunohistochemistry was performed using monoclonal antibodies on paraffin-embedded tissue sections. Expression was correlated with patient demographics and tumor pathologic features. Results: ERβ was expressed in 100{\%} (106 of 106) of the AML specimens evaluated. Of the 104 specimens that could be assessed for the AR, 82 (79{\%}) demonstrated staining. Of 110 lesions, 31 (28{\%}), 42 (38{\%}), and 11 (10{\%}) expressed ERα, progesterone receptor, and aromatase, respectively. The level of ERβ expression was not associated with patient age (P = 0.92), sex (P = 0.82), a diagnosis of tuberous sclerosis (P = 0.56), or histologic subtype of AML (P = 0.94). A trend was found toward increased AR expression in men (P = 0.069) and younger patients (P = 0.052), and ERα was expressed in the AML specimens from 5 (71{\%}) of 7 patients with tuberous sclerosis compared with 26 (25{\%}) of 103 without tuberous sclerosis (P = 0.018). Both AR and ERα expression were more common in the triphasic subtype of AML than in the lipomatous tumors (P = 0.046 for both). Conclusions: The results of our study have shown that ERβ expression is ubiquitous in renal AML, and the AR is found in most tumors. ERα and progesterone receptor were expressed in approximately one third of cases. These data suggest a potential role for hormones in the pathogenesis and management of renal AML.",
author = "Boorjian, {Stephen A.} and Yuri Sheinin and Crispen, {Paul L.} and Lohse, {Christine M.} and Kwon, {Eugene D} and Leibovich, {Bradley C.}",
year = "2008",
month = "10",
doi = "10.1016/j.urology.2008.01.067",
language = "English (US)",
volume = "72",
pages = "927--932",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Hormone Receptor Expression in Renal Angiomyolipoma

T2 - Clinicopathologic Correlation

AU - Boorjian, Stephen A.

AU - Sheinin, Yuri

AU - Crispen, Paul L.

AU - Lohse, Christine M.

AU - Kwon, Eugene D

AU - Leibovich, Bradley C.

PY - 2008/10

Y1 - 2008/10

N2 - Objectives: Although renal angiomyolipoma (AML) occurs more commonly in females than males, the origin of this difference in incidence by sex is unknown. Therefore, we investigated the expression of the androgen receptor (AR), estrogen receptor subtypes alpha (ERα) and beta (ERβ), progesterone receptor, and the enzyme aromatase in renal AML. Methods: We evaluated specimens from 110 patients who had undergone resection of a renal AML, including 90 women and 20 men. Immunohistochemistry was performed using monoclonal antibodies on paraffin-embedded tissue sections. Expression was correlated with patient demographics and tumor pathologic features. Results: ERβ was expressed in 100% (106 of 106) of the AML specimens evaluated. Of the 104 specimens that could be assessed for the AR, 82 (79%) demonstrated staining. Of 110 lesions, 31 (28%), 42 (38%), and 11 (10%) expressed ERα, progesterone receptor, and aromatase, respectively. The level of ERβ expression was not associated with patient age (P = 0.92), sex (P = 0.82), a diagnosis of tuberous sclerosis (P = 0.56), or histologic subtype of AML (P = 0.94). A trend was found toward increased AR expression in men (P = 0.069) and younger patients (P = 0.052), and ERα was expressed in the AML specimens from 5 (71%) of 7 patients with tuberous sclerosis compared with 26 (25%) of 103 without tuberous sclerosis (P = 0.018). Both AR and ERα expression were more common in the triphasic subtype of AML than in the lipomatous tumors (P = 0.046 for both). Conclusions: The results of our study have shown that ERβ expression is ubiquitous in renal AML, and the AR is found in most tumors. ERα and progesterone receptor were expressed in approximately one third of cases. These data suggest a potential role for hormones in the pathogenesis and management of renal AML.

AB - Objectives: Although renal angiomyolipoma (AML) occurs more commonly in females than males, the origin of this difference in incidence by sex is unknown. Therefore, we investigated the expression of the androgen receptor (AR), estrogen receptor subtypes alpha (ERα) and beta (ERβ), progesterone receptor, and the enzyme aromatase in renal AML. Methods: We evaluated specimens from 110 patients who had undergone resection of a renal AML, including 90 women and 20 men. Immunohistochemistry was performed using monoclonal antibodies on paraffin-embedded tissue sections. Expression was correlated with patient demographics and tumor pathologic features. Results: ERβ was expressed in 100% (106 of 106) of the AML specimens evaluated. Of the 104 specimens that could be assessed for the AR, 82 (79%) demonstrated staining. Of 110 lesions, 31 (28%), 42 (38%), and 11 (10%) expressed ERα, progesterone receptor, and aromatase, respectively. The level of ERβ expression was not associated with patient age (P = 0.92), sex (P = 0.82), a diagnosis of tuberous sclerosis (P = 0.56), or histologic subtype of AML (P = 0.94). A trend was found toward increased AR expression in men (P = 0.069) and younger patients (P = 0.052), and ERα was expressed in the AML specimens from 5 (71%) of 7 patients with tuberous sclerosis compared with 26 (25%) of 103 without tuberous sclerosis (P = 0.018). Both AR and ERα expression were more common in the triphasic subtype of AML than in the lipomatous tumors (P = 0.046 for both). Conclusions: The results of our study have shown that ERβ expression is ubiquitous in renal AML, and the AR is found in most tumors. ERα and progesterone receptor were expressed in approximately one third of cases. These data suggest a potential role for hormones in the pathogenesis and management of renal AML.

UR - http://www.scopus.com/inward/record.url?scp=52949129082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52949129082&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2008.01.067

DO - 10.1016/j.urology.2008.01.067

M3 - Article

VL - 72

SP - 927

EP - 932

JO - Urology

JF - Urology

SN - 0090-4295

IS - 4

ER -