Hormonal responses to graded surgical stress

B. Chernow, H. R. Alexander, Robert Christian Smallridge, W. R. Thompson, D. Cook, D. Beardsley, M. P. Fink, C. R. Lake, J. R. Fletcher

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that selected hormonal responses to surgery reflect the degree of surgical stress. Plasma norepinephrine, epinephrine, thromboxane B2, cortisol, serum angiotensin converting enzyme, thyroxine, triiodothyronine, free thyroxine, and free triiodothyronine levels were measured preoperatively, and then one hour, 24 hours, and five days postoperatively in three groups of patients. The groups were as follows: group 1, 'minimal' stress, eg, inguinal hernia repair (n = 10); group 2, 'moderate' stress, eg, cholecystectomy (n = 12); and group 3, 'severe' stress, eg, subtotal colectomy (n = 9). Patients in group 1 showed no significant surgery-induced changes in hormonal values. The stress-induced changes in patients in groups 2 and 3 were seen at one and occasionally 24 hours; however, by five days postoperatively, circulating hormone values had returned to preoperative levels. Increases in plasma cortisol, norepinephrine, and epinephrine, and decreases in serum angiotensin converting enzyme levels characterized the surgery-induced hormonal changes. Conclusions are as follows: (1) hormonal responses do reflect the degree of surgical stress; (2) the hormonal changes are transient, lasting no longer than 24 hours in patients after uncomplicated surgery; (3) hormonal responses to minimal surgical stress are negligible.

Original languageEnglish (US)
Pages (from-to)1273-1280
Number of pages8
JournalArchives of Internal Medicine
Volume147
Issue number7
DOIs
StatePublished - 1987
Externally publishedYes

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Triiodothyronine
Peptidyl-Dipeptidase A
Thyroxine
Epinephrine
Hydrocortisone
Norepinephrine
Thromboxane B2
Colectomy
Inguinal Hernia
Herniorrhaphy
Cholecystectomy
Serum
Hormones

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Chernow, B., Alexander, H. R., Smallridge, R. C., Thompson, W. R., Cook, D., Beardsley, D., ... Fletcher, J. R. (1987). Hormonal responses to graded surgical stress. Archives of Internal Medicine, 147(7), 1273-1280. https://doi.org/10.1001/archinte.147.7.1273

Hormonal responses to graded surgical stress. / Chernow, B.; Alexander, H. R.; Smallridge, Robert Christian; Thompson, W. R.; Cook, D.; Beardsley, D.; Fink, M. P.; Lake, C. R.; Fletcher, J. R.

In: Archives of Internal Medicine, Vol. 147, No. 7, 1987, p. 1273-1280.

Research output: Contribution to journalArticle

Chernow, B, Alexander, HR, Smallridge, RC, Thompson, WR, Cook, D, Beardsley, D, Fink, MP, Lake, CR & Fletcher, JR 1987, 'Hormonal responses to graded surgical stress', Archives of Internal Medicine, vol. 147, no. 7, pp. 1273-1280. https://doi.org/10.1001/archinte.147.7.1273
Chernow B, Alexander HR, Smallridge RC, Thompson WR, Cook D, Beardsley D et al. Hormonal responses to graded surgical stress. Archives of Internal Medicine. 1987;147(7):1273-1280. https://doi.org/10.1001/archinte.147.7.1273
Chernow, B. ; Alexander, H. R. ; Smallridge, Robert Christian ; Thompson, W. R. ; Cook, D. ; Beardsley, D. ; Fink, M. P. ; Lake, C. R. ; Fletcher, J. R. / Hormonal responses to graded surgical stress. In: Archives of Internal Medicine. 1987 ; Vol. 147, No. 7. pp. 1273-1280.
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