Hormonal regulation of human muscle protein metabolism

Olav E. Rooyackers, K Sreekumaran Nair

Research output: Contribution to journalArticle

  • 146 Citations

Abstract

A continuous turnover of protein (synthesis and breakdown) maintains the functional integrity and quality of skeletal muscle. Hormones are important regulators of this remodeling process. Anabolic hormones stimulate human muscle growth mainly by increasing protein synthesis (growth hormone, insulin-like growth factors, and testosterone) or by decreasing protein breakdown (insulin). Unlike in growing animals, insulin's main anabolic effect on muscle protein in adult humans is an inhibition of protein breakdown. Protein synthesis is stimulated only in the presence of a high amino acid supply. A combination of the stress hormones (glucagon, glucocorticoids, and catecholamines) cause muscle catabolism, but the effects of the individual hormones on human muscle and their mechanisms of action remain to be clearly defined. Although thyroid hormone is essential during growth, both an excess and a deficiency cause muscle wasting by yet unknown mechanisms. A greater understanding of the regulation of human muscle protein metabolism is essential to elucidate mechanisms of muscle wasting.

LanguageEnglish (US)
Pages457-485
Number of pages29
JournalAnnual Review of Nutrition
Volume17
DOIs
StatePublished - 1997

Fingerprint

Muscle Proteins
Muscles
Hormones
Proteins
Anabolic Agents
Somatomedins
Growth
Glucagon
Thyroid Hormones
Glucocorticoids
Growth Hormone
Catecholamines
Testosterone
Skeletal Muscle
Insulin
Amino Acids

Keywords

  • Growth hormone
  • Insulin
  • Protein breakdown
  • Protein synthesis
  • Skeletal muscle

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Hormonal regulation of human muscle protein metabolism. / Rooyackers, Olav E.; Nair, K Sreekumaran.

In: Annual Review of Nutrition, Vol. 17, 1997, p. 457-485.

Research output: Contribution to journalArticle

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