Hormonal and signaling role of branched-chain amino acids

K Sreekumaran Nair, Kevin R. Short

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Amino acids (AAs), especially BCAAs, play pivotal roles in hormonal secretion and action as well as in intracellular signaling. There is emerging data showing that BCAAs regulate gene transcription and translation. Signaling proteins such as the mammalian target of rapamycin act as sensors of BCAAs, especially leucine, to modulate anabolic action. AAs stimulate protein synthesis and inhibit protein breakdown in skeletal muscle and liver. The specific role of BCAAs in regulating synthesis and breakdown of individual protein or proteins with common function or functions remains to be defined. Future studies should also focus on potential adverse effects of BCAAs on insulin sensitivity, renal function, and tumor growth. It also remains to be determined whether potential adverse effects of BCAA supplementation is similar in people of different age groups.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume135
Issue number6 SUPPL.
StatePublished - Jun 2005

Fingerprint

Branched Chain Amino Acids
branched chain amino acids
Proteins
proteins
adverse effects
amino acids
renal function
Amino Acids
insulin resistance
translation (genetics)
leucine
skeletal muscle
Sirolimus
transcription (genetics)
Leucine
protein synthesis
secretion
Insulin Resistance
Skeletal Muscle
Age Groups

Keywords

  • Branched-chain amino acids
  • Hormonal action
  • Hormonal secretion
  • Protein breakdown
  • Protein synthesis
  • Signaling

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Hormonal and signaling role of branched-chain amino acids. / Nair, K Sreekumaran; Short, Kevin R.

In: Journal of Nutrition, Vol. 135, No. 6 SUPPL., 06.2005.

Research output: Contribution to journalArticle

@article{6e546a203ac5490c872f2a4202556ced,
title = "Hormonal and signaling role of branched-chain amino acids",
abstract = "Amino acids (AAs), especially BCAAs, play pivotal roles in hormonal secretion and action as well as in intracellular signaling. There is emerging data showing that BCAAs regulate gene transcription and translation. Signaling proteins such as the mammalian target of rapamycin act as sensors of BCAAs, especially leucine, to modulate anabolic action. AAs stimulate protein synthesis and inhibit protein breakdown in skeletal muscle and liver. The specific role of BCAAs in regulating synthesis and breakdown of individual protein or proteins with common function or functions remains to be defined. Future studies should also focus on potential adverse effects of BCAAs on insulin sensitivity, renal function, and tumor growth. It also remains to be determined whether potential adverse effects of BCAA supplementation is similar in people of different age groups.",
keywords = "Branched-chain amino acids, Hormonal action, Hormonal secretion, Protein breakdown, Protein synthesis, Signaling",
author = "Nair, {K Sreekumaran} and Short, {Kevin R.}",
year = "2005",
month = "6",
language = "English (US)",
volume = "135",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "6 SUPPL.",

}

TY - JOUR

T1 - Hormonal and signaling role of branched-chain amino acids

AU - Nair, K Sreekumaran

AU - Short, Kevin R.

PY - 2005/6

Y1 - 2005/6

N2 - Amino acids (AAs), especially BCAAs, play pivotal roles in hormonal secretion and action as well as in intracellular signaling. There is emerging data showing that BCAAs regulate gene transcription and translation. Signaling proteins such as the mammalian target of rapamycin act as sensors of BCAAs, especially leucine, to modulate anabolic action. AAs stimulate protein synthesis and inhibit protein breakdown in skeletal muscle and liver. The specific role of BCAAs in regulating synthesis and breakdown of individual protein or proteins with common function or functions remains to be defined. Future studies should also focus on potential adverse effects of BCAAs on insulin sensitivity, renal function, and tumor growth. It also remains to be determined whether potential adverse effects of BCAA supplementation is similar in people of different age groups.

AB - Amino acids (AAs), especially BCAAs, play pivotal roles in hormonal secretion and action as well as in intracellular signaling. There is emerging data showing that BCAAs regulate gene transcription and translation. Signaling proteins such as the mammalian target of rapamycin act as sensors of BCAAs, especially leucine, to modulate anabolic action. AAs stimulate protein synthesis and inhibit protein breakdown in skeletal muscle and liver. The specific role of BCAAs in regulating synthesis and breakdown of individual protein or proteins with common function or functions remains to be defined. Future studies should also focus on potential adverse effects of BCAAs on insulin sensitivity, renal function, and tumor growth. It also remains to be determined whether potential adverse effects of BCAA supplementation is similar in people of different age groups.

KW - Branched-chain amino acids

KW - Hormonal action

KW - Hormonal secretion

KW - Protein breakdown

KW - Protein synthesis

KW - Signaling

UR - http://www.scopus.com/inward/record.url?scp=20344399405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20344399405&partnerID=8YFLogxK

M3 - Article

C2 - 15930467

AN - SCOPUS:20344399405

VL - 135

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 6 SUPPL.

ER -