Honeycomb Epithelial Edema Associated With Rho Kinase Inhibition: A Case Series and Review of the Literature

Lance J. Lyons; Kristi Y. Wu; Keith H. Baratz; Arthur J. Sit

doi:10.1097/ICO.0000000000002694

Honeycomb Epithelial Edema Associated With Rho Kinase Inhibition: A Case Series and Review of the Literature

Lance J. Lyons, Kristi Y. Wu, Keith H. Baratz, Arthur J. Sit

Ophthalmology

Research output: Contribution to journal › Review article › peer-review

Abstract

The Rho kinase inhibitor netarsudil is a recently approved therapeutic option for the management of increased intraocular pressure in the United States. Although phase 3 clinical trials noted corneal changes related to the medication-namely, nonvisually-significant corneal verticillata-descriptions of a unique form of cystic epithelial edema began to surface as netarsudil (and its sister drug ripasudil, approved in Japan) gained widespread use. This series adds 3 new cases and reviews the current literature on this unique side effect.

Original language	English (US)
Pages (from-to)	243-248
Number of pages	6
Journal	Cornea
Volume	41
Issue number	2
DOIs	https://doi.org/10.1097/ICO.0000000000002694
State	Published - Feb 1 2022

Keywords

Cornea
Edema
Honeycomb
Netarsudil
Ripasudil

ASJC Scopus subject areas

Ophthalmology

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10.1097/ICO.0000000000002694

Cite this

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title = "Honeycomb Epithelial Edema Associated With Rho Kinase Inhibition: A Case Series and Review of the Literature",

abstract = "The Rho kinase inhibitor netarsudil is a recently approved therapeutic option for the management of increased intraocular pressure in the United States. Although phase 3 clinical trials noted corneal changes related to the medication-namely, nonvisually-significant corneal verticillata-descriptions of a unique form of cystic epithelial edema began to surface as netarsudil (and its sister drug ripasudil, approved in Japan) gained widespread use. This series adds 3 new cases and reviews the current literature on this unique side effect.",

keywords = "Cornea, Edema, Honeycomb, Netarsudil, Ripasudil",

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year = "2022",

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doi = "10.1097/ICO.0000000000002694",

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T1 - Honeycomb Epithelial Edema Associated With Rho Kinase Inhibition

T2 - A Case Series and Review of the Literature

AU - Lyons, Lance J.

AU - Wu, Kristi Y.

AU - Baratz, Keith H.

AU - Sit, Arthur J.

PY - 2022/2/1

Y1 - 2022/2/1

N2 - The Rho kinase inhibitor netarsudil is a recently approved therapeutic option for the management of increased intraocular pressure in the United States. Although phase 3 clinical trials noted corneal changes related to the medication-namely, nonvisually-significant corneal verticillata-descriptions of a unique form of cystic epithelial edema began to surface as netarsudil (and its sister drug ripasudil, approved in Japan) gained widespread use. This series adds 3 new cases and reviews the current literature on this unique side effect.

AB - The Rho kinase inhibitor netarsudil is a recently approved therapeutic option for the management of increased intraocular pressure in the United States. Although phase 3 clinical trials noted corneal changes related to the medication-namely, nonvisually-significant corneal verticillata-descriptions of a unique form of cystic epithelial edema began to surface as netarsudil (and its sister drug ripasudil, approved in Japan) gained widespread use. This series adds 3 new cases and reviews the current literature on this unique side effect.

KW - Cornea

KW - Edema

KW - Honeycomb

KW - Netarsudil

KW - Ripasudil

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M3 - Review article

C2 - 35037906

AN - SCOPUS:85123567139

SN - 0277-3740

VL - 41

SP - 243

EP - 248

JO - Cornea

JF - Cornea

IS - 2

ER -

Honeycomb Epithelial Edema Associated With Rho Kinase Inhibition: A Case Series and Review of the Literature

Abstract

Keywords

ASJC Scopus subject areas

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