Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation

Seung H. Kang, Rima C. Abdel-Massih, Robert A. Brown, Ross A. Dierkhising, Walter K Kremers, Raymund R Razonable

Research output: Contribution to journalArticle

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Abstract

Immunity against cytomegalovirus (CMV) is initiated after its recognition by Toll-like receptor 2 (TLR2). We assessed the association between a single-nucleotide polymorphism (SNP) that impairs TLR2 function and CMV disease in a cohort of 737 liver recipients. Ninety-two of 737 patients (7.1%, 10.9%, 12.3%, and 12.5% by 3, 6, 12, and 24 months, respectively) developed CMV disease. Kaplan-Meier estimation demonstrated an association between TLR2 R753Q SNP homozygosity and CMV disease (P =. 044), especially tissue-invasive CMV disease (P =. 001). A multivariate Cox proportional hazard model that accounted for other significant predictors demonstrated a significant association between TLR2 R753Q SNP homozygosity and tissue-invasive CMV disease (hazard ratio, 3.407; 95% confidence interval, 1.518-7.644; P =. 0029). In conclusion, homozygosity for TLR2 R753Q SNP is a marker for CMV disease risk, especially for tissue-invasive disease, after liver transplantation. This observation supports the critical role of TLR2 in the pathogenesis of CMV disease in humans.

Original languageEnglish (US)
Pages (from-to)639-646
Number of pages8
JournalJournal of Infectious Diseases
Volume205
Issue number4
DOIs
StatePublished - Feb 15 2012

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Toll-Like Receptor 2
Cytomegalovirus
Liver Transplantation
Single Nucleotide Polymorphism
Proportional Hazards Models
Immunity
Confidence Intervals
Liver

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation. / Kang, Seung H.; Abdel-Massih, Rima C.; Brown, Robert A.; Dierkhising, Ross A.; Kremers, Walter K; Razonable, Raymund R.

In: Journal of Infectious Diseases, Vol. 205, No. 4, 15.02.2012, p. 639-646.

Research output: Contribution to journalArticle

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abstract = "Immunity against cytomegalovirus (CMV) is initiated after its recognition by Toll-like receptor 2 (TLR2). We assessed the association between a single-nucleotide polymorphism (SNP) that impairs TLR2 function and CMV disease in a cohort of 737 liver recipients. Ninety-two of 737 patients (7.1{\%}, 10.9{\%}, 12.3{\%}, and 12.5{\%} by 3, 6, 12, and 24 months, respectively) developed CMV disease. Kaplan-Meier estimation demonstrated an association between TLR2 R753Q SNP homozygosity and CMV disease (P =. 044), especially tissue-invasive CMV disease (P =. 001). A multivariate Cox proportional hazard model that accounted for other significant predictors demonstrated a significant association between TLR2 R753Q SNP homozygosity and tissue-invasive CMV disease (hazard ratio, 3.407; 95{\%} confidence interval, 1.518-7.644; P =. 0029). In conclusion, homozygosity for TLR2 R753Q SNP is a marker for CMV disease risk, especially for tissue-invasive disease, after liver transplantation. This observation supports the critical role of TLR2 in the pathogenesis of CMV disease in humans.",
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AU - Kremers, Walter K

AU - Razonable, Raymund R

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