TY - JOUR
T1 - Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation
AU - Kang, Seung H.
AU - Abdel-Massih, Rima C.
AU - Brown, Robert A.
AU - Dierkhising, Ross A.
AU - Kremers, Walter K.
AU - Razonable, Raymund R.
N1 - Funding Information:
Financial support. This work was supported by National Institutes of Health, National Center for Research Resources, Center for Translational Science Activities (NCRR CTSA) (grant UL1 RR024150); the CR20 Award from the Clinical and Translational Science Activities, Mayo Clinic (to R. R. R.); and the Mayo Transplant Center Scholarly Award (to R. R. R). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health. Potential conflicts of interest. All authors: No reported conflicts.
PY - 2012/2/15
Y1 - 2012/2/15
N2 - Immunity against cytomegalovirus (CMV) is initiated after its recognition by Toll-like receptor 2 (TLR2). We assessed the association between a single-nucleotide polymorphism (SNP) that impairs TLR2 function and CMV disease in a cohort of 737 liver recipients. Ninety-two of 737 patients (7.1%, 10.9%, 12.3%, and 12.5% by 3, 6, 12, and 24 months, respectively) developed CMV disease. Kaplan-Meier estimation demonstrated an association between TLR2 R753Q SNP homozygosity and CMV disease (P =. 044), especially tissue-invasive CMV disease (P =. 001). A multivariate Cox proportional hazard model that accounted for other significant predictors demonstrated a significant association between TLR2 R753Q SNP homozygosity and tissue-invasive CMV disease (hazard ratio, 3.407; 95% confidence interval, 1.518-7.644; P =. 0029). In conclusion, homozygosity for TLR2 R753Q SNP is a marker for CMV disease risk, especially for tissue-invasive disease, after liver transplantation. This observation supports the critical role of TLR2 in the pathogenesis of CMV disease in humans.
AB - Immunity against cytomegalovirus (CMV) is initiated after its recognition by Toll-like receptor 2 (TLR2). We assessed the association between a single-nucleotide polymorphism (SNP) that impairs TLR2 function and CMV disease in a cohort of 737 liver recipients. Ninety-two of 737 patients (7.1%, 10.9%, 12.3%, and 12.5% by 3, 6, 12, and 24 months, respectively) developed CMV disease. Kaplan-Meier estimation demonstrated an association between TLR2 R753Q SNP homozygosity and CMV disease (P =. 044), especially tissue-invasive CMV disease (P =. 001). A multivariate Cox proportional hazard model that accounted for other significant predictors demonstrated a significant association between TLR2 R753Q SNP homozygosity and tissue-invasive CMV disease (hazard ratio, 3.407; 95% confidence interval, 1.518-7.644; P =. 0029). In conclusion, homozygosity for TLR2 R753Q SNP is a marker for CMV disease risk, especially for tissue-invasive disease, after liver transplantation. This observation supports the critical role of TLR2 in the pathogenesis of CMV disease in humans.
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U2 - 10.1093/infdis/jir819
DO - 10.1093/infdis/jir819
M3 - Article
C2 - 22219347
AN - SCOPUS:84863012906
SN - 0022-1899
VL - 205
SP - 639
EP - 646
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -