Homocysteine effects on brain volumes mapped in 732 elderly individuals

Priya Rajagopalan, Xue Hua, Arthur W. Toga, Clifford R Jr. Jack, Michael W. Weiner, Paul M. Thompson

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Elevated homocysteine levels are a known risk factor for Alzheimer's disease and vascular disorders. Here we applied tensor-based morphometry to brain magnetic resonance imaging scans of 732 elderly individuals from the Alzheimer's Disease Neuroimaging Initiative study, to determine associations between homocysteine and brain atrophy. Those with higher homocysteine levels showed greater frontal, parietal, and occipital white matter atrophy in the entire cohort, irrespective of diagnosis, age, or sex. This association was also found when considering mild cognitive impairment individuals separately. Vitamin B supplements, such as folate, may help prevent homocysteine-related atrophy in Alzheimer's disease by possibly reducing homocysteine levels. These atrophy profiles may, in the future, offer a potential biomarker to gauge the efficacy of interventions using dietary folate supplementation.

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalNeuroReport
Volume22
Issue number8
DOIs
StatePublished - Jun 11 2011

Fingerprint

Homocysteine
Atrophy
Brain
Alzheimer Disease
Folic Acid
Vitamin B Complex
Dietary Supplements
Neuroimaging
Blood Vessels
Biomarkers
Magnetic Resonance Imaging

Keywords

  • Alzheimer's disease
  • atrophy
  • brain structure
  • folate
  • homocysteine
  • magnetic resonance imaging
  • vitamin B

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rajagopalan, P., Hua, X., Toga, A. W., Jack, C. R. J., Weiner, M. W., & Thompson, P. M. (2011). Homocysteine effects on brain volumes mapped in 732 elderly individuals. NeuroReport, 22(8), 391-395. https://doi.org/10.1097/WNR.0b013e328346bf85

Homocysteine effects on brain volumes mapped in 732 elderly individuals. / Rajagopalan, Priya; Hua, Xue; Toga, Arthur W.; Jack, Clifford R Jr.; Weiner, Michael W.; Thompson, Paul M.

In: NeuroReport, Vol. 22, No. 8, 11.06.2011, p. 391-395.

Research output: Contribution to journalArticle

Rajagopalan, P, Hua, X, Toga, AW, Jack, CRJ, Weiner, MW & Thompson, PM 2011, 'Homocysteine effects on brain volumes mapped in 732 elderly individuals', NeuroReport, vol. 22, no. 8, pp. 391-395. https://doi.org/10.1097/WNR.0b013e328346bf85
Rajagopalan, Priya ; Hua, Xue ; Toga, Arthur W. ; Jack, Clifford R Jr. ; Weiner, Michael W. ; Thompson, Paul M. / Homocysteine effects on brain volumes mapped in 732 elderly individuals. In: NeuroReport. 2011 ; Vol. 22, No. 8. pp. 391-395.
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