Homocysteine effects on brain volumes mapped in 732 elderly individuals

Priya Rajagopalan; Xue Hua; Arthur W. Toga; Clifford R. Jack; Michael W. Weiner; Paul M. Thompson

doi:10.1097/WNR.0b013e328346bf85

Homocysteine effects on brain volumes mapped in 732 elderly individuals

Priya Rajagopalan, Xue Hua, Arthur W. Toga, Clifford R. Jack, Michael W. Weiner, Paul M. Thompson

Radiology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Elevated homocysteine levels are a known risk factor for Alzheimer's disease and vascular disorders. Here we applied tensor-based morphometry to brain magnetic resonance imaging scans of 732 elderly individuals from the Alzheimer's Disease Neuroimaging Initiative study, to determine associations between homocysteine and brain atrophy. Those with higher homocysteine levels showed greater frontal, parietal, and occipital white matter atrophy in the entire cohort, irrespective of diagnosis, age, or sex. This association was also found when considering mild cognitive impairment individuals separately. Vitamin B supplements, such as folate, may help prevent homocysteine-related atrophy in Alzheimer's disease by possibly reducing homocysteine levels. These atrophy profiles may, in the future, offer a potential biomarker to gauge the efficacy of interventions using dietary folate supplementation.

Original language	English (US)
Pages (from-to)	391-395
Number of pages	5
Journal	NeuroReport
Volume	22
Issue number	8
DOIs	https://doi.org/10.1097/WNR.0b013e328346bf85
State	Published - Jun 11 2011

Keywords

Alzheimer's disease
atrophy
brain structure
folate
homocysteine
magnetic resonance imaging
vitamin B

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1097/WNR.0b013e328346bf85

Cite this

@article{953b917af84a431b8fe08e87b8118ce3,

title = "Homocysteine effects on brain volumes mapped in 732 elderly individuals",

abstract = "Elevated homocysteine levels are a known risk factor for Alzheimer's disease and vascular disorders. Here we applied tensor-based morphometry to brain magnetic resonance imaging scans of 732 elderly individuals from the Alzheimer's Disease Neuroimaging Initiative study, to determine associations between homocysteine and brain atrophy. Those with higher homocysteine levels showed greater frontal, parietal, and occipital white matter atrophy in the entire cohort, irrespective of diagnosis, age, or sex. This association was also found when considering mild cognitive impairment individuals separately. Vitamin B supplements, such as folate, may help prevent homocysteine-related atrophy in Alzheimer's disease by possibly reducing homocysteine levels. These atrophy profiles may, in the future, offer a potential biomarker to gauge the efficacy of interventions using dietary folate supplementation.",

keywords = "Alzheimer's disease, atrophy, brain structure, folate, homocysteine, magnetic resonance imaging, vitamin B",

author = "Priya Rajagopalan and Xue Hua and Toga, {Arthur W.} and Jack, {Clifford R.} and Weiner, {Michael W.} and Thompson, {Paul M.}",

year = "2011",

month = jun,

day = "11",

doi = "10.1097/WNR.0b013e328346bf85",

language = "English (US)",

volume = "22",

pages = "391--395",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "8",

}

TY - JOUR

T1 - Homocysteine effects on brain volumes mapped in 732 elderly individuals

AU - Rajagopalan, Priya

AU - Hua, Xue

AU - Toga, Arthur W.

AU - Jack, Clifford R.

AU - Weiner, Michael W.

AU - Thompson, Paul M.

PY - 2011/6/11

Y1 - 2011/6/11

N2 - Elevated homocysteine levels are a known risk factor for Alzheimer's disease and vascular disorders. Here we applied tensor-based morphometry to brain magnetic resonance imaging scans of 732 elderly individuals from the Alzheimer's Disease Neuroimaging Initiative study, to determine associations between homocysteine and brain atrophy. Those with higher homocysteine levels showed greater frontal, parietal, and occipital white matter atrophy in the entire cohort, irrespective of diagnosis, age, or sex. This association was also found when considering mild cognitive impairment individuals separately. Vitamin B supplements, such as folate, may help prevent homocysteine-related atrophy in Alzheimer's disease by possibly reducing homocysteine levels. These atrophy profiles may, in the future, offer a potential biomarker to gauge the efficacy of interventions using dietary folate supplementation.

AB - Elevated homocysteine levels are a known risk factor for Alzheimer's disease and vascular disorders. Here we applied tensor-based morphometry to brain magnetic resonance imaging scans of 732 elderly individuals from the Alzheimer's Disease Neuroimaging Initiative study, to determine associations between homocysteine and brain atrophy. Those with higher homocysteine levels showed greater frontal, parietal, and occipital white matter atrophy in the entire cohort, irrespective of diagnosis, age, or sex. This association was also found when considering mild cognitive impairment individuals separately. Vitamin B supplements, such as folate, may help prevent homocysteine-related atrophy in Alzheimer's disease by possibly reducing homocysteine levels. These atrophy profiles may, in the future, offer a potential biomarker to gauge the efficacy of interventions using dietary folate supplementation.

KW - Alzheimer's disease

KW - atrophy

KW - brain structure

KW - folate

KW - homocysteine

KW - magnetic resonance imaging

KW - vitamin B

UR - http://www.scopus.com/inward/record.url?scp=79955624743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955624743&partnerID=8YFLogxK

U2 - 10.1097/WNR.0b013e328346bf85

DO - 10.1097/WNR.0b013e328346bf85

M3 - Article

C2 - 21512418

AN - SCOPUS:79955624743

SN - 0959-4965

VL - 22

SP - 391

EP - 395

JO - NeuroReport

JF - NeuroReport

IS - 8

ER -

Homocysteine effects on brain volumes mapped in 732 elderly individuals

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this