Holeboard performance of rats after hippocampal lesions and treatment with nimodipine

Cynthia Weichman, Pamela McMurray, Grace Knuttinen, Peter Mudd, Elisabeth A. Foley, Stanley Finger

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Rats were taught to select eight holes in a 4 × 4 holeboard for food reinforcements. Upon reaching criterion, they were given subtotal lesions of the anterior hippocampus or sham operations. They then received either the calcium channel blocker, nimodipine, or vehicle alone. Retention testing revealed a significant main effect of lesion and evidence for nimodipine reducing this effect. These data are consistent with previous findings from this laboratory in which it was demonstrated that nimodipine can enhance performance on higher cognitive tasks after hippocampal damage.

Original languageEnglish (US)
Pages (from-to)278-283
Number of pages6
JournalExperimental Neurology
Volume127
Issue number2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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