Hodgkin lymphoma: MOPP chemotherapy to PD-1 blockade and beyond

Hodgkin lymphoma is a rare lymphoid malignancy affecting ~9,200 new patients in the United States annually. Progress in the management of this disease over the past 50 years has been remarkable and the prognosis of this malignancy has changed from a uniformly fatal process to one in which the vast majority of patients are expected to be cured. This remarkable progress has been due to the use of combination approaches incorporating chemotherapy and radiation therapy, and now more recently antibody-drug conjugates and immune checkpoint inhibitors. The goal for the future is to develop treatment combinations that successfully treat all patients and markedly decrease the long-term side effects. Am. J. Hematol. 91:109-112, 2016.