HLA‐linked susceptibility to rheumatoid arthritis in North India

N. K. Mehra; R. Kaul; V. Taneja; T. K. Chaudhuri; B. Jhinghan; A. N. Malaviya

doi:10.1111/j.1399-0039.1988.tb02084.x

HLA‐linked susceptibility to rheumatoid arthritis in North India

N. K. Mehra, R. Kaul, V. Taneja, T. K. Chaudhuri, B. Jhinghan, A. N. Malaviya

Immunology

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4 Scopus citations

Abstract

Nine multiplex RA families of North Indian origin were tissue typed to determine the segregation of parental haplotypes among sibs. The assortment of haplotypes in 18 affected sibs was not random, with seven sib pairs being HLA identical and two haploidentical with the proband (P = 0.0007). HLA‐DR4 occurred in eight out of nine probands (88.8%) and in 11 out of 13 familial RA subjects (84.6%).

Original language	English (US)
Pages (from-to)	220-223
Number of pages	4
Journal	Tissue Antigens
Volume	31
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-0039.1988.tb02084.x
State	Published - Apr 1988

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Genetics

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abstract = "Nine multiplex RA families of North Indian origin were tissue typed to determine the segregation of parental haplotypes among sibs. The assortment of haplotypes in 18 affected sibs was not random, with seven sib pairs being HLA identical and two haploidentical with the proband (P = 0.0007). HLA‐DR4 occurred in eight out of nine probands (88.8%) and in 11 out of 13 familial RA subjects (84.6%).",

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AU - Mehra, N. K.

AU - Kaul, R.

AU - Taneja, V.

AU - Chaudhuri, T. K.

AU - Jhinghan, B.

AU - Malaviya, A. N.

PY - 1988/4

Y1 - 1988/4

N2 - Nine multiplex RA families of North Indian origin were tissue typed to determine the segregation of parental haplotypes among sibs. The assortment of haplotypes in 18 affected sibs was not random, with seven sib pairs being HLA identical and two haploidentical with the proband (P = 0.0007). HLA‐DR4 occurred in eight out of nine probands (88.8%) and in 11 out of 13 familial RA subjects (84.6%).

AB - Nine multiplex RA families of North Indian origin were tissue typed to determine the segregation of parental haplotypes among sibs. The assortment of haplotypes in 18 affected sibs was not random, with seven sib pairs being HLA identical and two haploidentical with the proband (P = 0.0007). HLA‐DR4 occurred in eight out of nine probands (88.8%) and in 11 out of 13 familial RA subjects (84.6%).

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HLA‐linked susceptibility to rheumatoid arthritis in North India

Abstract

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