HLA transgenic mice as models of human autoimmune diseases

P. Das, R. Abraham, C. David

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

MHC class II alleles have been linked to several human autoimmune diseases such as rheumatoid arthritis (RA), Type I diabetes, and multiple sclerosis (MS). Although the mechanisms by which expression of certain MHC class II molecules predispose an individual to a particular autoimmune disease are not known, it is clear that increased susceptibility is associated with the polymorphic regions unique to these predisposing HLA alleles. These polymorphic differences may influence susceptibility by selecting potential autoreactive T cells during thymic education. Alternatively, nonsusceptible alleles may either delete or fail to select these potential autoimmune T cells, thus reducing the possibility of developing disease. In the periphery, the unique specificity of the HLA molecule derived from a susceptible allele may then recognize and present an autoantigenic peptide or foreign peptide that may cross-react with an autoantigen, activating these autoreactive T cells and leading to disease. To dissect these possibilities and to determine the exact role of particular HLA-DR or DQ molecules in disease susceptibility, we have generated several lines of HLA-DR and DQ transgenic mice. In this review, we present data summarizing the functions of these HLA class II molecules using well-established mouse models for autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)105-114
Number of pages10
JournalReviews in Immunogenetics
Volume2
Issue number1
StatePublished - Mar 22 2000

Keywords

  • Autoantigens
  • Autoimmunity
  • Human Leukocyte Antigen (HLA)
  • Major Histocompatibility Complex (MHC) class II
  • T cells
  • Transgenic

ASJC Scopus subject areas

  • Immunology
  • Genetics

Fingerprint Dive into the research topics of 'HLA transgenic mice as models of human autoimmune diseases'. Together they form a unique fingerprint.

  • Cite this

    Das, P., Abraham, R., & David, C. (2000). HLA transgenic mice as models of human autoimmune diseases. Reviews in Immunogenetics, 2(1), 105-114.