HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: Findings and implications for vaccine design

Inna G. Ovsyannikova, Robert M. Jacobson, Robert A. Vierkant, Vernon Shane Pankratz, Gregory A. Poland

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Although the outcome of the immune response to measles-mumps-rubella (MMR) vaccination depends on multiple factors, elucidation of specific host genetic markers, such as HLA supertypes based on a shared sequence motif in the peptide-binding pockets of HLA molecules, is essential. We studied the association between measures of humoral and cellular immune responses and HLA supertypes among 346 children previously immunized with two doses of MMR. We found that HLA supertypes, such as A3, B7, B44, B58, B62, and DR may play a role in modulating immune responses to the measles and mumps components of MMR vaccine. This information may be of significant value in the engineering of potential epitope-based vaccines that are recognized by T cells restricted by human HLA supertype alleles.

Original languageEnglish (US)
Pages (from-to)3090-3100
Number of pages11
JournalVaccine
Volume25
Issue number16 SPEC. ISS.
DOIs
StatePublished - Apr 20 2007

Keywords

  • HLA supertypes
  • Immunity
  • MMR vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Ovsyannikova, I. G., Jacobson, R. M., Vierkant, R. A., Pankratz, V. S., & Poland, G. A. (2007). HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: Findings and implications for vaccine design. Vaccine, 25(16 SPEC. ISS.), 3090-3100. https://doi.org/10.1016/j.vaccine.2007.01.020