HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: Findings and implications for vaccine design

Inna G. Ovsyannikova, Robert M. Jacobson, Robert A. Vierkant, V. Shane Pankratz, Gregory A. Poland

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Although the outcome of the immune response to measles-mumps-rubella (MMR) vaccination depends on multiple factors, elucidation of specific host genetic markers, such as HLA supertypes based on a shared sequence motif in the peptide-binding pockets of HLA molecules, is essential. We studied the association between measures of humoral and cellular immune responses and HLA supertypes among 346 children previously immunized with two doses of MMR. We found that HLA supertypes, such as A3, B7, B44, B58, B62, and DR may play a role in modulating immune responses to the measles and mumps components of MMR vaccine. This information may be of significant value in the engineering of potential epitope-based vaccines that are recognized by T cells restricted by human HLA supertype alleles.

Original languageEnglish (US)
Pages (from-to)3090-3100
Number of pages11
JournalVaccine
Volume25
Issue number16 SPEC. ISS.
DOIs
StatePublished - Apr 20 2007

Fingerprint

Measles-Mumps-Rubella Vaccine
Viral Vaccines
Mumps
Measles
Vaccines
Rubella
immune response
vaccines
humoral immunity
cell-mediated immunity
epitopes
engineering
T-lymphocytes
vaccination
peptides
Humoral Immunity
alleles
Genetic Markers
Cellular Immunity
genetic markers

Keywords

  • HLA supertypes
  • Immunity
  • MMR vaccine

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Ovsyannikova, I. G., Jacobson, R. M., Vierkant, R. A., Pankratz, V. S., & Poland, G. A. (2007). HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: Findings and implications for vaccine design. Vaccine, 25(16 SPEC. ISS.), 3090-3100. https://doi.org/10.1016/j.vaccine.2007.01.020

HLA supertypes and immune responses to measles-mumps-rubella viral vaccine : Findings and implications for vaccine design. / Ovsyannikova, Inna G.; Jacobson, Robert M.; Vierkant, Robert A.; Pankratz, V. Shane; Poland, Gregory A.

In: Vaccine, Vol. 25, No. 16 SPEC. ISS., 20.04.2007, p. 3090-3100.

Research output: Contribution to journalArticle

Ovsyannikova, IG, Jacobson, RM, Vierkant, RA, Pankratz, VS & Poland, GA 2007, 'HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: Findings and implications for vaccine design', Vaccine, vol. 25, no. 16 SPEC. ISS., pp. 3090-3100. https://doi.org/10.1016/j.vaccine.2007.01.020
Ovsyannikova, Inna G. ; Jacobson, Robert M. ; Vierkant, Robert A. ; Pankratz, V. Shane ; Poland, Gregory A. / HLA supertypes and immune responses to measles-mumps-rubella viral vaccine : Findings and implications for vaccine design. In: Vaccine. 2007 ; Vol. 25, No. 16 SPEC. ISS. pp. 3090-3100.
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