HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish

Owen A. Ross; Martin D. Curran; I. Maeve Rea; Paul Hyland; Orla Duggan; Christopher R. Barnett; Kathryn Annett; Chris Patterson; Yvonne A. Barnett; Derek Middleton

doi:10.1016/S0047-6374(03)00037-X

HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish

Owen A. Ross, Martin D. Curran, I. Maeve Rea, Paul Hyland, Orla Duggan, Christopher R. Barnett, Kathryn Annett, Chris Patterson, Yvonne A. Barnett, Derek Middleton

Neuroscience

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Polymorphism of the human leukocyte antigen has been implicated in a number of autoimmune disorders including ageing. In the course of the present study, no association of the human leukocyte antigen (HLA)-A1, B8, DR3 haplotype with a male Irish aged population, as previously reported, was observed. Two polymorphic nucleotides in the TNF cluster (G-308A TNF-α and G+252A TNF-β), associated with increased TNF-α production, were shown to be in tight linkage disequilibrium with the class I and II HLA loci, generating HLA haplotypes with extended linkage disequilibrium. However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide.

Original language	English (US)
Pages (from-to)	563-567
Number of pages	5
Journal	Mechanisms of Ageing and Development
Volume	124
Issue number	4
DOIs	https://doi.org/10.1016/S0047-6374(03)00037-X
State	Published - Apr 1 2003

Keywords

HLA
Immunosenescence
Polymorphism
TNF

ASJC Scopus subject areas

Aging
Developmental Biology

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10.1016/S0047-6374(03)00037-X

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title = "HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish",

abstract = "Polymorphism of the human leukocyte antigen has been implicated in a number of autoimmune disorders including ageing. In the course of the present study, no association of the human leukocyte antigen (HLA)-A1, B8, DR3 haplotype with a male Irish aged population, as previously reported, was observed. Two polymorphic nucleotides in the TNF cluster (G-308A TNF-α and G+252A TNF-β), associated with increased TNF-α production, were shown to be in tight linkage disequilibrium with the class I and II HLA loci, generating HLA haplotypes with extended linkage disequilibrium. However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide.",

keywords = "HLA, Immunosenescence, Polymorphism, TNF",

author = "Ross, {Owen A.} and Curran, {Martin D.} and Rea, {I. Maeve} and Paul Hyland and Orla Duggan and Barnett, {Christopher R.} and Kathryn Annett and Chris Patterson and Barnett, {Yvonne A.} and Derek Middleton",

note = "Funding Information: The authors wish to acknowledge The European Union for support under the aegis of European Union Concerted Action on the Molecular Biology of Immunosenescence (EUCAMBIS; Biomed 1 contract CT94-1209); and Immunology and Ageing in Europe (IMAGINE; QLK6-CT-1999-O2031). OA Ross was a recipient of a CAST Award jointly funded by the Department of Education and Learning (Northern Ireland) and the Histocompatibility and Immunogenetics Charitable Trust Fund.",

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doi = "10.1016/S0047-6374(03)00037-X",

language = "English (US)",

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T1 - HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish

AU - Ross, Owen A.

AU - Curran, Martin D.

AU - Rea, I. Maeve

AU - Hyland, Paul

AU - Duggan, Orla

AU - Barnett, Christopher R.

AU - Annett, Kathryn

AU - Patterson, Chris

AU - Barnett, Yvonne A.

AU - Middleton, Derek

N1 - Funding Information: The authors wish to acknowledge The European Union for support under the aegis of European Union Concerted Action on the Molecular Biology of Immunosenescence (EUCAMBIS; Biomed 1 contract CT94-1209); and Immunology and Ageing in Europe (IMAGINE; QLK6-CT-1999-O2031). OA Ross was a recipient of a CAST Award jointly funded by the Department of Education and Learning (Northern Ireland) and the Histocompatibility and Immunogenetics Charitable Trust Fund.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Polymorphism of the human leukocyte antigen has been implicated in a number of autoimmune disorders including ageing. In the course of the present study, no association of the human leukocyte antigen (HLA)-A1, B8, DR3 haplotype with a male Irish aged population, as previously reported, was observed. Two polymorphic nucleotides in the TNF cluster (G-308A TNF-α and G+252A TNF-β), associated with increased TNF-α production, were shown to be in tight linkage disequilibrium with the class I and II HLA loci, generating HLA haplotypes with extended linkage disequilibrium. However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide.

AB - Polymorphism of the human leukocyte antigen has been implicated in a number of autoimmune disorders including ageing. In the course of the present study, no association of the human leukocyte antigen (HLA)-A1, B8, DR3 haplotype with a male Irish aged population, as previously reported, was observed. Two polymorphic nucleotides in the TNF cluster (G-308A TNF-α and G+252A TNF-β), associated with increased TNF-α production, were shown to be in tight linkage disequilibrium with the class I and II HLA loci, generating HLA haplotypes with extended linkage disequilibrium. However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide.

KW - HLA

KW - Immunosenescence

KW - Polymorphism

KW - TNF

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AN - SCOPUS:0037398764

SN - 0047-6374

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JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

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ER -

HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish

Abstract

Keywords

ASJC Scopus subject areas

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