HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish

Owen A. Ross, Martin D. Curran, I. Maeve Rea, Paul Hyland, Orla Duggan, Christopher R. Barnett, Kathryn Annett, Chris Patterson, Yvonne A. Barnett, Derek Middleton

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Polymorphism of the human leukocyte antigen has been implicated in a number of autoimmune disorders including ageing. In the course of the present study, no association of the human leukocyte antigen (HLA)-A1, B8, DR3 haplotype with a male Irish aged population, as previously reported, was observed. Two polymorphic nucleotides in the TNF cluster (G-308A TNF-α and G+252A TNF-β), associated with increased TNF-α production, were shown to be in tight linkage disequilibrium with the class I and II HLA loci, generating HLA haplotypes with extended linkage disequilibrium. However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide.

Original languageEnglish (US)
Pages (from-to)563-567
Number of pages5
JournalMechanisms of Ageing and Development
Issue number4
StatePublished - Apr 1 2003


  • HLA
  • Immunosenescence
  • Polymorphism
  • TNF

ASJC Scopus subject areas

  • Aging
  • Developmental Biology


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