HLA haplotype sharing and proband genotype in IDDM

J. I. Rotter, C. M. Vadheim, Gloria M Petersen

Research output: Contribution to journalArticle

Abstract

We previously proposed that the HLA-related genetic susceptibility to insulin dependent diabetes mellitus (IDDM) is best explained by at least two different susceptibility alleles, one preferentially associated with DR3, the other with DR4. This IDDM HLA heterogeneity model predicts that HLA haplotype sharing among affected sibpairs will be increased when the index case is a compound heterozygote (i.e., DR3/DR4). This prediction was tested and confirmed using the GAW IV IDDM data set. A significantly increased sharing of HLA haplotypes was seen when the index sib was DR3/DR4 compared to those of other genotypes (68% versus 37% sharing 2 haplotypes, p<.01).

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalGenetic Epidemiology
Volume3
Issue numberSUPPL. 1
StatePublished - 1986
Externally publishedYes

Fingerprint

Type 1 Diabetes Mellitus
Haplotypes
Genotype
Genetic Predisposition to Disease
Heterozygote
Alleles

ASJC Scopus subject areas

  • Medicine(all)
  • Epidemiology
  • Genetics(clinical)

Cite this

Rotter, J. I., Vadheim, C. M., & Petersen, G. M. (1986). HLA haplotype sharing and proband genotype in IDDM. Genetic Epidemiology, 3(SUPPL. 1), 347-352.

HLA haplotype sharing and proband genotype in IDDM. / Rotter, J. I.; Vadheim, C. M.; Petersen, Gloria M.

In: Genetic Epidemiology, Vol. 3, No. SUPPL. 1, 1986, p. 347-352.

Research output: Contribution to journalArticle

Rotter, JI, Vadheim, CM & Petersen, GM 1986, 'HLA haplotype sharing and proband genotype in IDDM', Genetic Epidemiology, vol. 3, no. SUPPL. 1, pp. 347-352.
Rotter, J. I. ; Vadheim, C. M. ; Petersen, Gloria M. / HLA haplotype sharing and proband genotype in IDDM. In: Genetic Epidemiology. 1986 ; Vol. 3, No. SUPPL. 1. pp. 347-352.
@article{5458141a06344ca185915b1062c2f3e2,
title = "HLA haplotype sharing and proband genotype in IDDM",
abstract = "We previously proposed that the HLA-related genetic susceptibility to insulin dependent diabetes mellitus (IDDM) is best explained by at least two different susceptibility alleles, one preferentially associated with DR3, the other with DR4. This IDDM HLA heterogeneity model predicts that HLA haplotype sharing among affected sibpairs will be increased when the index case is a compound heterozygote (i.e., DR3/DR4). This prediction was tested and confirmed using the GAW IV IDDM data set. A significantly increased sharing of HLA haplotypes was seen when the index sib was DR3/DR4 compared to those of other genotypes (68{\%} versus 37{\%} sharing 2 haplotypes, p<.01).",
author = "Rotter, {J. I.} and Vadheim, {C. M.} and Petersen, {Gloria M}",
year = "1986",
language = "English (US)",
volume = "3",
pages = "347--352",
journal = "Genetic Epidemiology",
issn = "0741-0395",
publisher = "Wiley-Liss Inc.",
number = "SUPPL. 1",

}

TY - JOUR

T1 - HLA haplotype sharing and proband genotype in IDDM

AU - Rotter, J. I.

AU - Vadheim, C. M.

AU - Petersen, Gloria M

PY - 1986

Y1 - 1986

N2 - We previously proposed that the HLA-related genetic susceptibility to insulin dependent diabetes mellitus (IDDM) is best explained by at least two different susceptibility alleles, one preferentially associated with DR3, the other with DR4. This IDDM HLA heterogeneity model predicts that HLA haplotype sharing among affected sibpairs will be increased when the index case is a compound heterozygote (i.e., DR3/DR4). This prediction was tested and confirmed using the GAW IV IDDM data set. A significantly increased sharing of HLA haplotypes was seen when the index sib was DR3/DR4 compared to those of other genotypes (68% versus 37% sharing 2 haplotypes, p<.01).

AB - We previously proposed that the HLA-related genetic susceptibility to insulin dependent diabetes mellitus (IDDM) is best explained by at least two different susceptibility alleles, one preferentially associated with DR3, the other with DR4. This IDDM HLA heterogeneity model predicts that HLA haplotype sharing among affected sibpairs will be increased when the index case is a compound heterozygote (i.e., DR3/DR4). This prediction was tested and confirmed using the GAW IV IDDM data set. A significantly increased sharing of HLA haplotypes was seen when the index sib was DR3/DR4 compared to those of other genotypes (68% versus 37% sharing 2 haplotypes, p<.01).

UR - http://www.scopus.com/inward/record.url?scp=0022828230&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022828230&partnerID=8YFLogxK

M3 - Article

C2 - 3569864

VL - 3

SP - 347

EP - 352

JO - Genetic Epidemiology

JF - Genetic Epidemiology

SN - 0741-0395

IS - SUPPL. 1

ER -