HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine

Inna G. Ovsyannikova, Robert A. Vierkant, V. Shane Pankratz, Megan M. O'Byrne, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Secreted rubella virus-specific cytokines reflect the immunologic mechanisms underlying adoptive immune responses and are significant markers of immunity to rubella. We studied the association between measures of cellular (cytokine and frequency of cytokine-secreted cells) immune responses and HLA haplotypes (with frequencies of ≥1%) and supertypes among 738 healthy children following two doses of rubella vaccine. Haplotype effects were estimated while accounting for linkage phase ambiguity via an expectation maximization algorithm. Importantly, the majority of HLA class I and class II haplotype associations with different cytokines were consistent between Th1, Th2 and/or innate/proinflammatory cytokine groups. We found few class I supertypes (A1, A2, A3, and B7) with potential associations with IL-10 ELISPOT counts and rubella-specific IL-2, IL-10, TNF-α, and IL-6 cytokine secretion levels. Our data indicate that the presence or absence of certain HLA haplotypes and/or supertypes may influence the cytokine immune response to rubella vaccine, and represents a more advanced analysis compared to individual candidate gene association studies.

Original languageEnglish (US)
Pages (from-to)3349-3358
Number of pages10
JournalVaccine
Volume27
Issue number25-26
DOIs
StatePublished - May 26 2009

Fingerprint

Rubella Vaccine
Cellular Immunity
cell-mediated immunity
Haplotypes
haplotypes
cytokines
Cytokines
vaccines
Rubella
immune response
interleukin-10
Interleukin-10
Rubella virus
Enzyme-Linked Immunospot Assay
Genetic Association Studies
interleukin-2
varespladib methyl
interleukin-6
Interleukin-2
linkage (genetics)

Keywords

  • Cytokines
  • ELISPOT
  • HLA class I haplotypes
  • HLA class II haplotypes
  • HLA supertypes
  • Rubella vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Ovsyannikova, I. G., Vierkant, R. A., Pankratz, V. S., O'Byrne, M. M., Jacobson, R. M., & Poland, G. A. (2009). HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine. Vaccine, 27(25-26), 3349-3358. https://doi.org/10.1016/j.vaccine.2009.01.080

HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine. / Ovsyannikova, Inna G.; Vierkant, Robert A.; Pankratz, V. Shane; O'Byrne, Megan M.; Jacobson, Robert M.; Poland, Gregory A.

In: Vaccine, Vol. 27, No. 25-26, 26.05.2009, p. 3349-3358.

Research output: Contribution to journalArticle

Ovsyannikova, IG, Vierkant, RA, Pankratz, VS, O'Byrne, MM, Jacobson, RM & Poland, GA 2009, 'HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine', Vaccine, vol. 27, no. 25-26, pp. 3349-3358. https://doi.org/10.1016/j.vaccine.2009.01.080
Ovsyannikova, Inna G. ; Vierkant, Robert A. ; Pankratz, V. Shane ; O'Byrne, Megan M. ; Jacobson, Robert M. ; Poland, Gregory A. / HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine. In: Vaccine. 2009 ; Vol. 27, No. 25-26. pp. 3349-3358.
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