HLA-DR/DQ antigens and reactivity to B cell alloantigen D8/17 in Indian patients with rheumatic heart disease

V. Taneja, N. K. Mehra, K. S. Reddy, J. Narula, R. Tandon, M. C. Vaidya, M. L. Bhatia

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

D8/17, a B cell alloantigen, and its occurrence with DR/DQ antigens was examined in 54 patients with rheumatic heart disease and matched North Indian controls. Thirty-four patients (62.9%) carried D8/17 as compared with a frequency of 12.5% in controls (χ2 by Yates', 18.75; p < 0.0001). A marginally increased frequency of human leukocyte antigen (HLA)-DR3 (44.2% vs. 28.8%) and a significantly reduced frequency of HLA-DR2 (21.1% vs. 46.6%; p < 0.005) was observed in patients as compared with controls. However, the most significant positive association was observed with HLA-DQw2 (63.4% in patients and 31.5% in controls; χ2 by Yates', 9.85; p < 0.005). The DQw2 association was significant only in the D8/17-positive patients. These observations suggest that the disease susceptibility gene in rheumatic heart disease may be nearer to the HLA-DQ locus than to the HLA-DR.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalCirculation
Volume80
Issue number2
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Taneja, V., Mehra, N. K., Reddy, K. S., Narula, J., Tandon, R., Vaidya, M. C., & Bhatia, M. L. (1989). HLA-DR/DQ antigens and reactivity to B cell alloantigen D8/17 in Indian patients with rheumatic heart disease. Circulation, 80(2), 335-340. https://doi.org/10.1161/01.CIR.80.2.335