TY - JOUR
T1 - HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice
T2 - Definitive association with HLA-DRB1*0301 (DR3) gene
AU - Kong, Yi Chi M.
AU - Lomo, Lesley C.
AU - Motte, Reinhard W.
AU - Giraldo, Alvaro A.
AU - Baisch, Jean
AU - Strauss, Gudrun
AU - Hämmerling, Gunter J.
AU - David, Chella S.
PY - 1996/9/1
Y1 - 1996/9/1
N2 - Familial clustering autoimmune thyroid diases has led to studies of their association with human major histocompatibility complex (MHC) class II genes. One such gene implicated in Hashimoto's thyroiditis (HT) is HLA-DR3, but the association is weak and is contradicted by other reports. On the other hand, murine experimental autoimmune thyroiditis (EAT), a model for HT, presents a clear linkage with MHC class II. Moreover, it is inducible with thyroglobulin (Tg), the common autoantigen in either species. Immunization of HA-DRB1*0301 (DR3) transgenic with mouse or human Tg resulted in severe thyroiditis. In contrast, transgenic mice with mouse or human Tg resulted in severe thyroiditis. In contrast transgenic mice expressing the HLA-DRB1*1502 (DR2) gene were resistant to EAT. Our studies show that HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis and implicate Tg as an important autoantigen.
AB - Familial clustering autoimmune thyroid diases has led to studies of their association with human major histocompatibility complex (MHC) class II genes. One such gene implicated in Hashimoto's thyroiditis (HT) is HLA-DR3, but the association is weak and is contradicted by other reports. On the other hand, murine experimental autoimmune thyroiditis (EAT), a model for HT, presents a clear linkage with MHC class II. Moreover, it is inducible with thyroglobulin (Tg), the common autoantigen in either species. Immunization of HA-DRB1*0301 (DR3) transgenic with mouse or human Tg resulted in severe thyroiditis. In contrast, transgenic mice with mouse or human Tg resulted in severe thyroiditis. In contrast transgenic mice expressing the HLA-DRB1*1502 (DR2) gene were resistant to EAT. Our studies show that HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis and implicate Tg as an important autoantigen.
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U2 - 10.1084/jem.184.3.1167
DO - 10.1084/jem.184.3.1167
M3 - Article
C2 - 9064334
AN - SCOPUS:0029830079
SN - 0022-1007
VL - 184
SP - 1167
EP - 1172
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 3
ER -