HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation

G. Rajagopalan, A. Y. Tilahun, K. Iijima, C. S. David, H. Kita, Y. J. Juhn

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We and others have reported that HLA-DRB1*03 is associated with childhood asthma. To extend this observation and to prove this association, we sensitized and challenged either HLA-DR2 (HLA-DRB1*1502) or HLA-DR3 (HLA-DRB1*0301) transgenic mice with house-dust mite extract. Inflammatory cell counts and cytokine levels in the bronchoalveolar lavage (BAL) fluid between HLA-DR3 and DR2 mice were compared. HLA-DR3 transgenic mice had significantly elevated eosinophil counts, Interleukin-4 and Interleukin-13 levels in the BAL fluid but not interferron gamma-γ. Thus, our study suggests that HLA-DRB1*0301 plays an important role in mounting a Th2-predominant immune response to house dust mite and Th2-type inflammation in the lung.

Original languageEnglish (US)
Pages (from-to)589-592
Number of pages4
JournalTissue Antigens
Volume77
Issue number6
DOIs
StatePublished - Jun 1 2011

Keywords

  • Asthma
  • Epidemiology
  • Genetics
  • HLA-DR2
  • HLA-DR3
  • Human leukocyte antigen type
  • Major histocompatibility complex
  • Polymorphism
  • Transgenic mouse

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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