HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation

G. Rajagopalan; A. Y. Tilahun; K. Iijima; C. S. David; H. Kita; Y. J. Juhn

doi:10.1111/j.1399-0039.2010.01617.x

HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation

G. Rajagopalan, A. Y. Tilahun, K. Iijima, C. S. David, H. Kita, Y. J. Juhn

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We and others have reported that HLA-DRB1*03 is associated with childhood asthma. To extend this observation and to prove this association, we sensitized and challenged either HLA-DR2 (HLA-DRB1*1502) or HLA-DR3 (HLA-DRB1*0301) transgenic mice with house-dust mite extract. Inflammatory cell counts and cytokine levels in the bronchoalveolar lavage (BAL) fluid between HLA-DR3 and DR2 mice were compared. HLA-DR3 transgenic mice had significantly elevated eosinophil counts, Interleukin-4 and Interleukin-13 levels in the BAL fluid but not interferron gamma-γ. Thus, our study suggests that HLA-DRB1*0301 plays an important role in mounting a Th2-predominant immune response to house dust mite and Th2-type inflammation in the lung.

Original language	English (US)
Pages (from-to)	589-592
Number of pages	4
Journal	Tissue Antigens
Volume	77
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-0039.2010.01617.x
State	Published - Jun 2011

Keywords

Asthma
Epidemiology
Genetics
HLA-DR2
HLA-DR3
Human leukocyte antigen type
Major histocompatibility complex
Polymorphism
Transgenic mouse

ASJC Scopus subject areas

Genetics
Biochemistry
Immunology and Allergy
Immunology

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10.1111/j.1399-0039.2010.01617.x

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title = "HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation",

abstract = "We and others have reported that HLA-DRB1*03 is associated with childhood asthma. To extend this observation and to prove this association, we sensitized and challenged either HLA-DR2 (HLA-DRB1*1502) or HLA-DR3 (HLA-DRB1*0301) transgenic mice with house-dust mite extract. Inflammatory cell counts and cytokine levels in the bronchoalveolar lavage (BAL) fluid between HLA-DR3 and DR2 mice were compared. HLA-DR3 transgenic mice had significantly elevated eosinophil counts, Interleukin-4 and Interleukin-13 levels in the BAL fluid but not interferron gamma-γ. Thus, our study suggests that HLA-DRB1*0301 plays an important role in mounting a Th2-predominant immune response to house dust mite and Th2-type inflammation in the lung.",

keywords = "Asthma, Epidemiology, Genetics, HLA-DR2, HLA-DR3, Human leukocyte antigen type, Major histocompatibility complex, Polymorphism, Transgenic mouse",

author = "G. Rajagopalan and Tilahun, {A. Y.} and K. Iijima and David, {C. S.} and H. Kita and Juhn, {Y. J.}",

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AU - Rajagopalan, G.

AU - Tilahun, A. Y.

AU - Iijima, K.

AU - David, C. S.

AU - Kita, H.

AU - Juhn, Y. J.

PY - 2011/6

Y1 - 2011/6

N2 - We and others have reported that HLA-DRB1*03 is associated with childhood asthma. To extend this observation and to prove this association, we sensitized and challenged either HLA-DR2 (HLA-DRB1*1502) or HLA-DR3 (HLA-DRB1*0301) transgenic mice with house-dust mite extract. Inflammatory cell counts and cytokine levels in the bronchoalveolar lavage (BAL) fluid between HLA-DR3 and DR2 mice were compared. HLA-DR3 transgenic mice had significantly elevated eosinophil counts, Interleukin-4 and Interleukin-13 levels in the BAL fluid but not interferron gamma-γ. Thus, our study suggests that HLA-DRB1*0301 plays an important role in mounting a Th2-predominant immune response to house dust mite and Th2-type inflammation in the lung.

AB - We and others have reported that HLA-DRB1*03 is associated with childhood asthma. To extend this observation and to prove this association, we sensitized and challenged either HLA-DR2 (HLA-DRB1*1502) or HLA-DR3 (HLA-DRB1*0301) transgenic mice with house-dust mite extract. Inflammatory cell counts and cytokine levels in the bronchoalveolar lavage (BAL) fluid between HLA-DR3 and DR2 mice were compared. HLA-DR3 transgenic mice had significantly elevated eosinophil counts, Interleukin-4 and Interleukin-13 levels in the BAL fluid but not interferron gamma-γ. Thus, our study suggests that HLA-DRB1*0301 plays an important role in mounting a Th2-predominant immune response to house dust mite and Th2-type inflammation in the lung.

KW - Asthma

KW - Epidemiology

KW - Genetics

KW - HLA-DR2

KW - HLA-DR3

KW - Human leukocyte antigen type

KW - Major histocompatibility complex

KW - Polymorphism

KW - Transgenic mouse

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HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation

Abstract

Keywords

ASJC Scopus subject areas

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