HLA-DQβ chain can present mouse endogenous provirus MTV-9 product and clonally delete Tcr Vβ5+ and Vβ11+ T cells in transgenic mice

Paul Zhou, Michele K. Smart, Shen Cheng, Suresh Savarirayan, Hidetoshi Inoko, Chella S. David

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The elusive Mls gene(s) are mouse mammary tumor virus genes. The endogenous cotolerogen involved in the clonal deletion of Tcr Vβ5.1, 5.2, and 11 in H-2E+ mouse strains has been narrowed down to MTV-9. We demonstrate that similar to H-2Eα molecules, human DQw6β chain mediated clonal deletion of Tcr Vβ5.1, 5.2, and 11 also requires the MTV-9 gene product. This shows that human class II molecules can present mouse retroviral antigen. Further, backcross analysis involving [B10.M(DQb)×DBA/1] suggest a second cotolerogen in the B10.M background in the clonal deletion of Vβ5-bearing T cells.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalImmunogenetics
Volume35
Issue number4
DOIs
StatePublished - Mar 1 1992

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ASJC Scopus subject areas

  • Immunology
  • Genetics

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