HLA-DQβ chain can present mouse endogenous provirus MTV-9 product and clonally delete Tcr Vβ5+ and Vβ11+ T cells in transgenic mice

Paul Zhou, Michele K. Smart, Shen Cheng, Suresh Savarirayan, Hidetoshi Inoko, Chella S. David

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The elusive Mls gene(s) are mouse mammary tumor virus genes. The endogenous cotolerogen involved in the clonal deletion of Tcr Vβ5.1, 5.2, and 11 in H-2E+ mouse strains has been narrowed down to MTV-9. We demonstrate that similar to H-2Eα molecules, human DQw6β chain mediated clonal deletion of Tcr Vβ5.1, 5.2, and 11 also requires the MTV-9 gene product. This shows that human class II molecules can present mouse retroviral antigen. Further, backcross analysis involving [B10.M(DQb)×DBA/1] suggest a second cotolerogen in the B10.M background in the clonal deletion of Vβ5-bearing T cells.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalImmunogenetics
Volume35
Issue number4
DOIs
StatePublished - Mar 1992

ASJC Scopus subject areas

  • Immunology
  • Genetics

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