HLA-B27 and other predisposing factors in spondyloarthrapathies

Sanjay D. Khare, Harvinder S. Luthra, Chella S. David

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Studies from around the world have confirmed the association between HLA-B27 and human spondyloarthropathies. The onset of many HLA-B27-linked arthritides follows an infection with enterobacteria. How bacteria interact with HLA-B27 and modify the immune system to give rise to the clinical disease is currently unclear. The roles of other genetic factors, including major histocompatibility complex class II genes and other genes located within this region (Tap/Lmp), have been postulated in certain spondyloarthropathies. We are using transgenic and knockout mice to answer some of these unsolved issues. This review discusses recent findings from our laboratories.

Original languageEnglish (US)
Pages (from-to)282-291
Number of pages10
JournalCurrent opinion in rheumatology
Volume10
Issue number4
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Rheumatology

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