HLA ANTIGENS IN ASIAN INDIAN PATIENTS WITH Graves'DISEASE

N. TANDON; N. K. MEHRA; V. TANEJA; M. C. VAIDYA; N. KOCHUPILLAI

doi:10.1111/j.1365-2265.1990.tb00461.x

HLA ANTIGENS IN ASIAN INDIAN PATIENTS WITH Graves'DISEASE

N. TANDON, N. K. MEHRA, V. TANEJA, M. C. VAIDYA, N. KOCHUPILLAI

Immunology

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Abstract

A study of 57 Asian Indian patients with Graves'disease revealed a significant increase in the frequency of HLA‐DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA‐A10 (29.8% patients as opposed to 10.5% controls) and HLA‐B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA‐A10 and HLA‐B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10‐B8 and B8‐DR3, were found in significant linkage disequilibrium in our patients with Graves'disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age.

Original language	English (US)
Pages (from-to)	21-26
Number of pages	6
Journal	Clinical Endocrinology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2265.1990.tb00461.x
State	Published - Jul 1990

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "HLA ANTIGENS IN ASIAN INDIAN PATIENTS WITH Graves'DISEASE",

abstract = "A study of 57 Asian Indian patients with Graves'disease revealed a significant increase in the frequency of HLA‐DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA‐A10 (29.8% patients as opposed to 10.5% controls) and HLA‐B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA‐A10 and HLA‐B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10‐B8 and B8‐DR3, were found in significant linkage disequilibrium in our patients with Graves'disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age.",

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AU - VAIDYA, M. C.

AU - KOCHUPILLAI, N.

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AB - A study of 57 Asian Indian patients with Graves'disease revealed a significant increase in the frequency of HLA‐DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA‐A10 (29.8% patients as opposed to 10.5% controls) and HLA‐B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA‐A10 and HLA‐B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10‐B8 and B8‐DR3, were found in significant linkage disequilibrium in our patients with Graves'disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age.

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HLA ANTIGENS IN ASIAN INDIAN PATIENTS WITH Graves'DISEASE

Abstract

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