HLA antigens in Asian Indian patients with Graves' disease

N. Tandon, N. K. Mehra, Veena D Taneja, M. C. Vaidya, N. Kochupillai

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A study of 57 Asian Indian patients with Graves' disease revealed a significant increase in the frequency of HLA-DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA-A10 (29.8% patients as opposed to 10.5% controls) and HLA-B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA-A10 and HLA-B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10-B8 and B8-DR3, were found in significant linkage disequilibrium in our patients with Graves' disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalClinical Endocrinology
Volume33
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

Graves Disease
HLA Antigens
HLA-B8 Antigen
Haplotypes
antineoplaston A10
Linkage Disequilibrium
Phenotype
Population

ASJC Scopus subject areas

  • Endocrinology

Cite this

Tandon, N., Mehra, N. K., Taneja, V. D., Vaidya, M. C., & Kochupillai, N. (1990). HLA antigens in Asian Indian patients with Graves' disease. Clinical Endocrinology, 33(1), 21-26.

HLA antigens in Asian Indian patients with Graves' disease. / Tandon, N.; Mehra, N. K.; Taneja, Veena D; Vaidya, M. C.; Kochupillai, N.

In: Clinical Endocrinology, Vol. 33, No. 1, 1990, p. 21-26.

Research output: Contribution to journalArticle

Tandon, N, Mehra, NK, Taneja, VD, Vaidya, MC & Kochupillai, N 1990, 'HLA antigens in Asian Indian patients with Graves' disease', Clinical Endocrinology, vol. 33, no. 1, pp. 21-26.
Tandon N, Mehra NK, Taneja VD, Vaidya MC, Kochupillai N. HLA antigens in Asian Indian patients with Graves' disease. Clinical Endocrinology. 1990;33(1):21-26.
Tandon, N. ; Mehra, N. K. ; Taneja, Veena D ; Vaidya, M. C. ; Kochupillai, N. / HLA antigens in Asian Indian patients with Graves' disease. In: Clinical Endocrinology. 1990 ; Vol. 33, No. 1. pp. 21-26.
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