HLA antigens and myasthenia gravis in north India

N. K. Mehra, G. K. Ahuja, Veena D Taneja, M. C. Vaidya

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The HLA antigen distribution was studied in 37 north Indian patients with myasthenia gravis. The control group consisted of 118 normal, healthy individuals of the same ethnic group. The antigens showing the highest frequency were Bw21 (18.9% vs 4.2% p < 0.005), Bw35 (24.3% vs 6.8%, p < 0.005) and A9 (51.3% vs 30.5%, p < 0.025). HLA-B8 was increased nearly two fold in the myasthenia gravis patients (RR = 2.4) and was confined mainly to the young females without thymoma. The possibility that Bw21 and Bw35 might be the markers for susceptibility to autoimmune disorders in India is discussed. The observations also support those of others that HLA-B8 linked susceptibility gene is more frequently found in myasthenia gravis patients with thymic hyperplasia.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume46
Issue number4
StatePublished - 1983
Externally publishedYes

Fingerprint

Myasthenia Gravis
HLA Antigens
HLA-B8 Antigen
India
Thymus Hyperplasia
Thymoma
Ethnic Groups
Antigens
Control Groups
Genes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

HLA antigens and myasthenia gravis in north India. / Mehra, N. K.; Ahuja, G. K.; Taneja, Veena D; Vaidya, M. C.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 46, No. 4, 1983, p. 361-364.

Research output: Contribution to journalArticle

Mehra, NK, Ahuja, GK, Taneja, VD & Vaidya, MC 1983, 'HLA antigens and myasthenia gravis in north India', Journal of Neurology Neurosurgery and Psychiatry, vol. 46, no. 4, pp. 361-364.
Mehra, N. K. ; Ahuja, G. K. ; Taneja, Veena D ; Vaidya, M. C. / HLA antigens and myasthenia gravis in north India. In: Journal of Neurology Neurosurgery and Psychiatry. 1983 ; Vol. 46, No. 4. pp. 361-364.
@article{cd9841d45ae940feb69c93afcb680f24,
title = "HLA antigens and myasthenia gravis in north India",
abstract = "The HLA antigen distribution was studied in 37 north Indian patients with myasthenia gravis. The control group consisted of 118 normal, healthy individuals of the same ethnic group. The antigens showing the highest frequency were Bw21 (18.9{\%} vs 4.2{\%} p < 0.005), Bw35 (24.3{\%} vs 6.8{\%}, p < 0.005) and A9 (51.3{\%} vs 30.5{\%}, p < 0.025). HLA-B8 was increased nearly two fold in the myasthenia gravis patients (RR = 2.4) and was confined mainly to the young females without thymoma. The possibility that Bw21 and Bw35 might be the markers for susceptibility to autoimmune disorders in India is discussed. The observations also support those of others that HLA-B8 linked susceptibility gene is more frequently found in myasthenia gravis patients with thymic hyperplasia.",
author = "Mehra, {N. K.} and Ahuja, {G. K.} and Taneja, {Veena D} and Vaidya, {M. C.}",
year = "1983",
language = "English (US)",
volume = "46",
pages = "361--364",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "4",

}

TY - JOUR

T1 - HLA antigens and myasthenia gravis in north India

AU - Mehra, N. K.

AU - Ahuja, G. K.

AU - Taneja, Veena D

AU - Vaidya, M. C.

PY - 1983

Y1 - 1983

N2 - The HLA antigen distribution was studied in 37 north Indian patients with myasthenia gravis. The control group consisted of 118 normal, healthy individuals of the same ethnic group. The antigens showing the highest frequency were Bw21 (18.9% vs 4.2% p < 0.005), Bw35 (24.3% vs 6.8%, p < 0.005) and A9 (51.3% vs 30.5%, p < 0.025). HLA-B8 was increased nearly two fold in the myasthenia gravis patients (RR = 2.4) and was confined mainly to the young females without thymoma. The possibility that Bw21 and Bw35 might be the markers for susceptibility to autoimmune disorders in India is discussed. The observations also support those of others that HLA-B8 linked susceptibility gene is more frequently found in myasthenia gravis patients with thymic hyperplasia.

AB - The HLA antigen distribution was studied in 37 north Indian patients with myasthenia gravis. The control group consisted of 118 normal, healthy individuals of the same ethnic group. The antigens showing the highest frequency were Bw21 (18.9% vs 4.2% p < 0.005), Bw35 (24.3% vs 6.8%, p < 0.005) and A9 (51.3% vs 30.5%, p < 0.025). HLA-B8 was increased nearly two fold in the myasthenia gravis patients (RR = 2.4) and was confined mainly to the young females without thymoma. The possibility that Bw21 and Bw35 might be the markers for susceptibility to autoimmune disorders in India is discussed. The observations also support those of others that HLA-B8 linked susceptibility gene is more frequently found in myasthenia gravis patients with thymic hyperplasia.

UR - http://www.scopus.com/inward/record.url?scp=0020538895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020538895&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 361

EP - 364

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 4

ER -