Historical perspective and clinical implications of the Pelger-Huet cell

John M. Cunningham, Mrinal M. Patnaik, Dale E. Hammerschmidt, Gregory M. Vercellotti

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

The unique historical aspects of Pelger and Huet's discovery of the Pelger-Huet cell highlight the diagnostic challenge that this morphologic finding presents to the physician. Making the diagnosis of the benign autosomal dominant anomaly is complicated by the morphologically similar pseudo-Pelger-Huet cell, which can signify underlying myeloid dsyplasia. This article relates the history of the Pelger-Huet anomaly as well as describes the clinical significance and diagnostic workup for the finding of a Pelger-Huet cell on peripheral smear.

Original languageEnglish (US)
Pages (from-to)116-119
Number of pages4
JournalAmerican journal of hematology
Volume84
Issue number2
DOIs
StatePublished - Feb 2009

ASJC Scopus subject areas

  • Hematology

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