Historical notes: The road to peroral endoscopic myotomy

Christopher J. Gostout

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Submucosal endoscopy with saftey valve mucosal flap was developed in the animal laboratory of the Mayo Clinic Developmental Endoscopy Unit. This concept, and ultimately clinical technique, was an outgrowth of earlier efforts to improve endoscopic excision of mucosal disease by manipulating the submucosa. The ability of the mucosa to readily separate from the submucosa (delaminate) was the critical observation that was refined into a method transforming the submucosa into a working space while allowing the overlying mucosal flap to serve as a protective barrier.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalTechniques in Gastrointestinal Endoscopy
Issue number3
StatePublished - Jul 1 2013


  • Endoscopic submucosal dissection
  • Peroral endoscopic myotomy
  • Submucosa
  • Submucosal endoscopy
  • Submucosal endoscopy with mucosal flap

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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