Histopathology of fungal diseases of the lung

Anja Roden, Audrey N. Schuetz

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Fungal pneumonias can be a diagnostic problem. However, their recognition is important as they can pose a significant health risk, especially in the immunocompromised host. While many of these infections are accompanied by necrotizing or non-necrotizing granulomas, some might be characterized by cellular interstitial pneumonia, intra-alveolar frothy material or only minimal inflammatory change. Much of the tissue reaction is dependent on the immune status of the patient and the type of fungal organism. While many of the fungi can be identified in tissue, especially if using histochemical stains such as Grocott's Methenamine Silver (GMS) stain and/or Periodic Acid Schiff (PAS) stain, in some cases, these stains are negative and the organisms can only be identified in cultures or using special techniques such as PCR or fungal serology. Some fungi can be accurately identified in tissue based on morphologic features; others require culture for exact classification. Knowledge about immune status, geographic region and social history of the patient are helpful in identifying the fungus and, therefore, detailed clinical and travel histories are important. In this manuscript we aim to describe the most common fungal infections that occur in the lung, their morphologic features, and differential diagnoses.

Original languageEnglish (US)
Pages (from-to)530-549
Number of pages20
JournalSeminars in Diagnostic Pathology
Volume34
Issue number6
DOIs
StatePublished - Nov 1 2017

Fingerprint

Fungal Lung Diseases
Coloring Agents
Fungi
Methenamine
Periodic Acid
Mycoses
Interstitial Lung Diseases
Immunocompromised Host
Serology
Granuloma
Pneumonia
Differential Diagnosis
Polymerase Chain Reaction
Lung
Health
Infection

Keywords

  • Aspergillus
  • Fungal infection
  • Granuloma
  • Histoplasma
  • Immunocompromised host
  • Pneumocystis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Histopathology of fungal diseases of the lung. / Roden, Anja; Schuetz, Audrey N.

In: Seminars in Diagnostic Pathology, Vol. 34, No. 6, 01.11.2017, p. 530-549.

Research output: Contribution to journalReview article

Roden, Anja ; Schuetz, Audrey N. / Histopathology of fungal diseases of the lung. In: Seminars in Diagnostic Pathology. 2017 ; Vol. 34, No. 6. pp. 530-549.
@article{aa24260a2c4e4b7b9444af786c9bdfad,
title = "Histopathology of fungal diseases of the lung",
abstract = "Fungal pneumonias can be a diagnostic problem. However, their recognition is important as they can pose a significant health risk, especially in the immunocompromised host. While many of these infections are accompanied by necrotizing or non-necrotizing granulomas, some might be characterized by cellular interstitial pneumonia, intra-alveolar frothy material or only minimal inflammatory change. Much of the tissue reaction is dependent on the immune status of the patient and the type of fungal organism. While many of the fungi can be identified in tissue, especially if using histochemical stains such as Grocott's Methenamine Silver (GMS) stain and/or Periodic Acid Schiff (PAS) stain, in some cases, these stains are negative and the organisms can only be identified in cultures or using special techniques such as PCR or fungal serology. Some fungi can be accurately identified in tissue based on morphologic features; others require culture for exact classification. Knowledge about immune status, geographic region and social history of the patient are helpful in identifying the fungus and, therefore, detailed clinical and travel histories are important. In this manuscript we aim to describe the most common fungal infections that occur in the lung, their morphologic features, and differential diagnoses.",
keywords = "Aspergillus, Fungal infection, Granuloma, Histoplasma, Immunocompromised host, Pneumocystis",
author = "Anja Roden and Schuetz, {Audrey N.}",
year = "2017",
month = "11",
day = "1",
doi = "10.1053/j.semdp.2017.06.002",
language = "English (US)",
volume = "34",
pages = "530--549",
journal = "Seminars in Diagnostic Pathology",
issn = "0740-2570",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Histopathology of fungal diseases of the lung

AU - Roden, Anja

AU - Schuetz, Audrey N.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Fungal pneumonias can be a diagnostic problem. However, their recognition is important as they can pose a significant health risk, especially in the immunocompromised host. While many of these infections are accompanied by necrotizing or non-necrotizing granulomas, some might be characterized by cellular interstitial pneumonia, intra-alveolar frothy material or only minimal inflammatory change. Much of the tissue reaction is dependent on the immune status of the patient and the type of fungal organism. While many of the fungi can be identified in tissue, especially if using histochemical stains such as Grocott's Methenamine Silver (GMS) stain and/or Periodic Acid Schiff (PAS) stain, in some cases, these stains are negative and the organisms can only be identified in cultures or using special techniques such as PCR or fungal serology. Some fungi can be accurately identified in tissue based on morphologic features; others require culture for exact classification. Knowledge about immune status, geographic region and social history of the patient are helpful in identifying the fungus and, therefore, detailed clinical and travel histories are important. In this manuscript we aim to describe the most common fungal infections that occur in the lung, their morphologic features, and differential diagnoses.

AB - Fungal pneumonias can be a diagnostic problem. However, their recognition is important as they can pose a significant health risk, especially in the immunocompromised host. While many of these infections are accompanied by necrotizing or non-necrotizing granulomas, some might be characterized by cellular interstitial pneumonia, intra-alveolar frothy material or only minimal inflammatory change. Much of the tissue reaction is dependent on the immune status of the patient and the type of fungal organism. While many of the fungi can be identified in tissue, especially if using histochemical stains such as Grocott's Methenamine Silver (GMS) stain and/or Periodic Acid Schiff (PAS) stain, in some cases, these stains are negative and the organisms can only be identified in cultures or using special techniques such as PCR or fungal serology. Some fungi can be accurately identified in tissue based on morphologic features; others require culture for exact classification. Knowledge about immune status, geographic region and social history of the patient are helpful in identifying the fungus and, therefore, detailed clinical and travel histories are important. In this manuscript we aim to describe the most common fungal infections that occur in the lung, their morphologic features, and differential diagnoses.

KW - Aspergillus

KW - Fungal infection

KW - Granuloma

KW - Histoplasma

KW - Immunocompromised host

KW - Pneumocystis

UR - http://www.scopus.com/inward/record.url?scp=85021712527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021712527&partnerID=8YFLogxK

U2 - 10.1053/j.semdp.2017.06.002

DO - 10.1053/j.semdp.2017.06.002

M3 - Review article

VL - 34

SP - 530

EP - 549

JO - Seminars in Diagnostic Pathology

JF - Seminars in Diagnostic Pathology

SN - 0740-2570

IS - 6

ER -