Histopathology of familial versus nonfamilial dilated cardiomyopathy

Virginia V. Michels, Henry D. Tazelaar, David J. Driscoll, John C Jr. Burnett, Fletcher A Jr. Miller, A. Jamil Tajik, Richard J. Rodeheffer, Patricia P. Moll

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Idiopathic dilated cardiomyopathy is most likely a heterogenous group of diseases characterized by ventricular dilatation and dysfunction. Approximately 20% of patients with idiopathic dilated cardiomyopathy have familial disease, which may be inapparent by review of the family history alone. It has been suggested that histopathologic features, particularly the presence of bizarrely shaped mitochondria, may be useful in distinguishing familial from nonfamilial disease. We investigated 57 patients with dilated cardiomyopathy, 13 familial and 43nonfamilial or indeterminate. Pathologic examination of right endomyocardial biopsy specimens showed no significant differences between the familial, nonfamilial, or indeterminate groups by light microscopy or electron microscopy. We conclude that the distinction between familial and nonfamilial dilated cardiomyopathy cannot be made by histopathologic examination in most cases.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalCardiovascular Pathology
Volume2
Issue number4
DOIs
StatePublished - 1993

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Dilated Cardiomyopathy
Ventricular Dysfunction
Dilatation
Microscopy
Electron Microscopy
Mitochondria
Biopsy
Light
Familial dilated cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pathology and Forensic Medicine

Cite this

Histopathology of familial versus nonfamilial dilated cardiomyopathy. / Michels, Virginia V.; Tazelaar, Henry D.; Driscoll, David J.; Burnett, John C Jr.; Miller, Fletcher A Jr.; Jamil Tajik, A.; Rodeheffer, Richard J.; Moll, Patricia P.

In: Cardiovascular Pathology, Vol. 2, No. 4, 1993, p. 219-223.

Research output: Contribution to journalArticle

Michels, VV, Tazelaar, HD, Driscoll, DJ, Burnett, JCJ, Miller, FAJ, Jamil Tajik, A, Rodeheffer, RJ & Moll, PP 1993, 'Histopathology of familial versus nonfamilial dilated cardiomyopathy', Cardiovascular Pathology, vol. 2, no. 4, pp. 219-223. https://doi.org/10.1016/1054-8807(93)90027-Y
Michels, Virginia V. ; Tazelaar, Henry D. ; Driscoll, David J. ; Burnett, John C Jr. ; Miller, Fletcher A Jr. ; Jamil Tajik, A. ; Rodeheffer, Richard J. ; Moll, Patricia P. / Histopathology of familial versus nonfamilial dilated cardiomyopathy. In: Cardiovascular Pathology. 1993 ; Vol. 2, No. 4. pp. 219-223.
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