Histopathology of explanted collar button keratoprostheses

A clinicopathologic correlation

E. J. Dudenhoefer, M. Nouri, I. K. Gipson, Keith Baratz, A. S. Tisdale, T. P. Dryja, J. C. Abad, C. H. Dohlman

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Purpose. To compare the histopathology of three PMMA collar button type keratoprosthesis (KPro)/corneal specimens, explanted due to various complications, with that from one KPro/corneal specimen taken postmortem from an otherwise "healthy" enucleated eye. Methods. Patient 1 (chemical injury) had no problems for 3 years after KPro placement; the entire eye was obtained postmortem. Patient 2 (repeated graft failures, nonautoimmune disease) developed an "unlaserable" retroprosthesis membrane 4 months after KPro placement. A new KPro was placed. Patient 3 [ocular cicatricial pemphigoid (OCP)] developed tissue melt at the KPro-cornea interface 7 months after KPro placement, and the KPro was replaced. Patient 4 (OCP) developed progressive corneal melt around the KPro 3.5 years after placement resulting in replacement. All KPro/cornea specimens were processed and sectioned for histology with the KPro in place. Results. All patients exhibited growth of corneal or conjunctival derived epithelium under the KPro front plate. In patients 1 and 2, no epithelial downgrowth was noted and the keratocyte density appeared normal with few inflammatory cells present. Dense fibrous tissue was present behind the KPro in patient 2. Patients 3 and 4 showed massive inflammatory cell infiltration and tissue necrosis with "melt" adjacent to the stem resulting in epithelial downgrowth. Conclusions. Corneal inflammation and degradation after KPro placement correlate well with the preoperative diagnostic category. Patients with immune-related corneal surface disease can exhibit marked inflammatory responses leading to necrosis, stromal melting, and the formation of an epithelial fistula. In contrast, patients without autoimmune corneal disease demonstrate a remarkably noninflamed cornea with intact keratocytes and without epithelial ingrowth, commensurate with their clinical appearance.

Original languageEnglish (US)
Pages (from-to)424-428
Number of pages5
JournalCornea
Volume22
Issue number5
DOIs
StatePublished - Jul 1 2003

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Benign Mucous Membrane Pemphigoid
Cornea
Corneal Diseases
Necrosis
Polymethyl Methacrylate
Freezing
Autoimmune Diseases
Fistula
Histology
Epithelium
Inflammation
Transplants
Membranes
Wounds and Injuries
Growth

Keywords

  • Cornea
  • Corneal pathology
  • Graft failure
  • Keratoprosthesis
  • Ocular pemphigoid

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Dudenhoefer, E. J., Nouri, M., Gipson, I. K., Baratz, K., Tisdale, A. S., Dryja, T. P., ... Dohlman, C. H. (2003). Histopathology of explanted collar button keratoprostheses: A clinicopathologic correlation. Cornea, 22(5), 424-428. https://doi.org/10.1097/00003226-200307000-00007

Histopathology of explanted collar button keratoprostheses : A clinicopathologic correlation. / Dudenhoefer, E. J.; Nouri, M.; Gipson, I. K.; Baratz, Keith; Tisdale, A. S.; Dryja, T. P.; Abad, J. C.; Dohlman, C. H.

In: Cornea, Vol. 22, No. 5, 01.07.2003, p. 424-428.

Research output: Contribution to journalArticle

Dudenhoefer, EJ, Nouri, M, Gipson, IK, Baratz, K, Tisdale, AS, Dryja, TP, Abad, JC & Dohlman, CH 2003, 'Histopathology of explanted collar button keratoprostheses: A clinicopathologic correlation', Cornea, vol. 22, no. 5, pp. 424-428. https://doi.org/10.1097/00003226-200307000-00007
Dudenhoefer, E. J. ; Nouri, M. ; Gipson, I. K. ; Baratz, Keith ; Tisdale, A. S. ; Dryja, T. P. ; Abad, J. C. ; Dohlman, C. H. / Histopathology of explanted collar button keratoprostheses : A clinicopathologic correlation. In: Cornea. 2003 ; Vol. 22, No. 5. pp. 424-428.
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abstract = "Purpose. To compare the histopathology of three PMMA collar button type keratoprosthesis (KPro)/corneal specimens, explanted due to various complications, with that from one KPro/corneal specimen taken postmortem from an otherwise {"}healthy{"} enucleated eye. Methods. Patient 1 (chemical injury) had no problems for 3 years after KPro placement; the entire eye was obtained postmortem. Patient 2 (repeated graft failures, nonautoimmune disease) developed an {"}unlaserable{"} retroprosthesis membrane 4 months after KPro placement. A new KPro was placed. Patient 3 [ocular cicatricial pemphigoid (OCP)] developed tissue melt at the KPro-cornea interface 7 months after KPro placement, and the KPro was replaced. Patient 4 (OCP) developed progressive corneal melt around the KPro 3.5 years after placement resulting in replacement. All KPro/cornea specimens were processed and sectioned for histology with the KPro in place. Results. All patients exhibited growth of corneal or conjunctival derived epithelium under the KPro front plate. In patients 1 and 2, no epithelial downgrowth was noted and the keratocyte density appeared normal with few inflammatory cells present. Dense fibrous tissue was present behind the KPro in patient 2. Patients 3 and 4 showed massive inflammatory cell infiltration and tissue necrosis with {"}melt{"} adjacent to the stem resulting in epithelial downgrowth. Conclusions. Corneal inflammation and degradation after KPro placement correlate well with the preoperative diagnostic category. Patients with immune-related corneal surface disease can exhibit marked inflammatory responses leading to necrosis, stromal melting, and the formation of an epithelial fistula. In contrast, patients without autoimmune corneal disease demonstrate a remarkably noninflamed cornea with intact keratocytes and without epithelial ingrowth, commensurate with their clinical appearance.",
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T2 - A clinicopathologic correlation

AU - Dudenhoefer, E. J.

AU - Nouri, M.

AU - Gipson, I. K.

AU - Baratz, Keith

AU - Tisdale, A. S.

AU - Dryja, T. P.

AU - Abad, J. C.

AU - Dohlman, C. H.

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N2 - Purpose. To compare the histopathology of three PMMA collar button type keratoprosthesis (KPro)/corneal specimens, explanted due to various complications, with that from one KPro/corneal specimen taken postmortem from an otherwise "healthy" enucleated eye. Methods. Patient 1 (chemical injury) had no problems for 3 years after KPro placement; the entire eye was obtained postmortem. Patient 2 (repeated graft failures, nonautoimmune disease) developed an "unlaserable" retroprosthesis membrane 4 months after KPro placement. A new KPro was placed. Patient 3 [ocular cicatricial pemphigoid (OCP)] developed tissue melt at the KPro-cornea interface 7 months after KPro placement, and the KPro was replaced. Patient 4 (OCP) developed progressive corneal melt around the KPro 3.5 years after placement resulting in replacement. All KPro/cornea specimens were processed and sectioned for histology with the KPro in place. Results. All patients exhibited growth of corneal or conjunctival derived epithelium under the KPro front plate. In patients 1 and 2, no epithelial downgrowth was noted and the keratocyte density appeared normal with few inflammatory cells present. Dense fibrous tissue was present behind the KPro in patient 2. Patients 3 and 4 showed massive inflammatory cell infiltration and tissue necrosis with "melt" adjacent to the stem resulting in epithelial downgrowth. Conclusions. Corneal inflammation and degradation after KPro placement correlate well with the preoperative diagnostic category. Patients with immune-related corneal surface disease can exhibit marked inflammatory responses leading to necrosis, stromal melting, and the formation of an epithelial fistula. In contrast, patients without autoimmune corneal disease demonstrate a remarkably noninflamed cornea with intact keratocytes and without epithelial ingrowth, commensurate with their clinical appearance.

AB - Purpose. To compare the histopathology of three PMMA collar button type keratoprosthesis (KPro)/corneal specimens, explanted due to various complications, with that from one KPro/corneal specimen taken postmortem from an otherwise "healthy" enucleated eye. Methods. Patient 1 (chemical injury) had no problems for 3 years after KPro placement; the entire eye was obtained postmortem. Patient 2 (repeated graft failures, nonautoimmune disease) developed an "unlaserable" retroprosthesis membrane 4 months after KPro placement. A new KPro was placed. Patient 3 [ocular cicatricial pemphigoid (OCP)] developed tissue melt at the KPro-cornea interface 7 months after KPro placement, and the KPro was replaced. Patient 4 (OCP) developed progressive corneal melt around the KPro 3.5 years after placement resulting in replacement. All KPro/cornea specimens were processed and sectioned for histology with the KPro in place. Results. All patients exhibited growth of corneal or conjunctival derived epithelium under the KPro front plate. In patients 1 and 2, no epithelial downgrowth was noted and the keratocyte density appeared normal with few inflammatory cells present. Dense fibrous tissue was present behind the KPro in patient 2. Patients 3 and 4 showed massive inflammatory cell infiltration and tissue necrosis with "melt" adjacent to the stem resulting in epithelial downgrowth. Conclusions. Corneal inflammation and degradation after KPro placement correlate well with the preoperative diagnostic category. Patients with immune-related corneal surface disease can exhibit marked inflammatory responses leading to necrosis, stromal melting, and the formation of an epithelial fistula. In contrast, patients without autoimmune corneal disease demonstrate a remarkably noninflamed cornea with intact keratocytes and without epithelial ingrowth, commensurate with their clinical appearance.

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KW - Ocular pemphigoid

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