Histopathology of autoimmune bullous dermatoses: what's new?

Burak Tekin; Emma F. Johnson; Carilyn N. Wieland; Lawrence E. Gibson; Michael J. Camilleri; Amer N. Kalaaji; Nneka I. Comfere; Margot S. Peters; Julia S. Lehman

doi:10.1016/j.humpath.2022.06.021

Histopathology of autoimmune bullous dermatoses: what's new?

Burak Tekin, Emma F. Johnson, Carilyn N. Wieland, Lawrence E. Gibson, Michael J. Camilleri, Amer N. Kalaaji, Nneka I. Comfere, Margot S. Peters, Julia S. Lehman

Dermatology

Research output: Contribution to journal › Review article › peer-review

Abstract

Autoimmune bullous dermatoses are characterized by the presence of tissue-bound and often circulating pathogenic autoantibodies targeting structural components of the skin and/or mucous membranes. The diagnostic workup for this heterogeneous group of disorders consists of a multi-step process, of which the light microscopic examination is a crucial component. This review is organized following a classification scheme that is based on two main histopathologic features, namely level of intraepithelial split and composition of the inflammatory infiltrate. Overall, we aim to place emphasis on the histopathologic clues that can assist pathologists in differential diagnosis and review the updates in the literature.

Original language	English (US)
Pages (from-to)	69-89
Number of pages	21
Journal	Human Pathology
Volume	128
DOIs	https://doi.org/10.1016/j.humpath.2022.06.021
State	Published - Oct 2022

Keywords

Acantholysis
Autoimmune bullous
Dermatitis herpetiformis
Direct immunofluorescence
Immunobullous
Linear IgA bullous dermatosis
Pemphigoid
Pemphigus

ASJC Scopus subject areas

Pathology and Forensic Medicine

Access to Document

10.1016/j.humpath.2022.06.021

Cite this

@article{6ba2a591f90c469ead634455c9b6f6c2,

title = "Histopathology of autoimmune bullous dermatoses: what's new?",

abstract = "Autoimmune bullous dermatoses are characterized by the presence of tissue-bound and often circulating pathogenic autoantibodies targeting structural components of the skin and/or mucous membranes. The diagnostic workup for this heterogeneous group of disorders consists of a multi-step process, of which the light microscopic examination is a crucial component. This review is organized following a classification scheme that is based on two main histopathologic features, namely level of intraepithelial split and composition of the inflammatory infiltrate. Overall, we aim to place emphasis on the histopathologic clues that can assist pathologists in differential diagnosis and review the updates in the literature.",

keywords = "Acantholysis, Autoimmune bullous, Dermatitis herpetiformis, Direct immunofluorescence, Immunobullous, Linear IgA bullous dermatosis, Pemphigoid, Pemphigus",

author = "Burak Tekin and Johnson, {Emma F.} and Wieland, {Carilyn N.} and Gibson, {Lawrence E.} and Camilleri, {Michael J.} and Kalaaji, {Amer N.} and Comfere, {Nneka I.} and Peters, {Margot S.} and Lehman, {Julia S.}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = oct,

doi = "10.1016/j.humpath.2022.06.021",

language = "English (US)",

volume = "128",

pages = "69--89",

journal = "Human Pathology",

issn = "0046-8177",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Histopathology of autoimmune bullous dermatoses

T2 - what's new?

AU - Tekin, Burak

AU - Johnson, Emma F.

AU - Wieland, Carilyn N.

AU - Gibson, Lawrence E.

AU - Camilleri, Michael J.

AU - Kalaaji, Amer N.

AU - Comfere, Nneka I.

AU - Peters, Margot S.

AU - Lehman, Julia S.

PY - 2022/10

Y1 - 2022/10

N2 - Autoimmune bullous dermatoses are characterized by the presence of tissue-bound and often circulating pathogenic autoantibodies targeting structural components of the skin and/or mucous membranes. The diagnostic workup for this heterogeneous group of disorders consists of a multi-step process, of which the light microscopic examination is a crucial component. This review is organized following a classification scheme that is based on two main histopathologic features, namely level of intraepithelial split and composition of the inflammatory infiltrate. Overall, we aim to place emphasis on the histopathologic clues that can assist pathologists in differential diagnosis and review the updates in the literature.

AB - Autoimmune bullous dermatoses are characterized by the presence of tissue-bound and often circulating pathogenic autoantibodies targeting structural components of the skin and/or mucous membranes. The diagnostic workup for this heterogeneous group of disorders consists of a multi-step process, of which the light microscopic examination is a crucial component. This review is organized following a classification scheme that is based on two main histopathologic features, namely level of intraepithelial split and composition of the inflammatory infiltrate. Overall, we aim to place emphasis on the histopathologic clues that can assist pathologists in differential diagnosis and review the updates in the literature.

KW - Acantholysis

KW - Autoimmune bullous

KW - Dermatitis herpetiformis

KW - Direct immunofluorescence

KW - Immunobullous

KW - Linear IgA bullous dermatosis

KW - Pemphigoid

KW - Pemphigus

UR - http://www.scopus.com/inward/record.url?scp=85136186756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85136186756&partnerID=8YFLogxK

U2 - 10.1016/j.humpath.2022.06.021

DO - 10.1016/j.humpath.2022.06.021

M3 - Review article

C2 - 35764145

AN - SCOPUS:85136186756

SN - 0046-8177

VL - 128

SP - 69

EP - 89

JO - Human Pathology

JF - Human Pathology

ER -

Histopathology of autoimmune bullous dermatoses: what's new?

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this