Histopathological Features and p53 Nuclear Protein Staining as Predictors of Survival and Tumor Recurrence in Patients with Transitional Cell Carcinoma of Renal Pelvis

R. Brenton Terrell, John C. Cheville, William A. See, Michael B. Cohen

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Purpose: We determine which histopathological features are predictive of recurrence and cause-specific survival in renal pelvic transitional cell carcinoma. Materials and Methods: Univariant and multivariant analysis was done on material from 67 patients. Results: Univariate and multivariate analysis identified lamina propria invasion, grade 3 tumors and capillary-lymphatic invasion as predictors of disease-specific survival. Multicentric disease was the sole independent predictor of recurrence. Multicentric disease and lamina propria invasion were independent predictors of recurrence-free survival. Also, p53 over-expression was not statistically associated with any of the studied prognostic factors. Conclusions: Histopathological features remain the cornerstone of prognostic assessment for renal pelvic transitional cell carcinoma.

Original languageEnglish (US)
Pages (from-to)1342-1347
Number of pages6
JournalThe Journal of Urology
Volume154
Issue number4
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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