Histopathological changes in the gastrointestinal tract due to medications: An update for the surgical pathologist (part ii of ii)

Giovanni De Petris, Sonia Gatius Caldero, Longwen Chen, Shu Yuan Xiao, Bal M. Dhungel, Amy J. Wendel Spizcka, Dora Lam-Himlin

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

In keeping with the stated goal of providing the surgical pathologist with tools to recognize abnormalities of the gastrointestinal (GI) tract due to drugs (AGIDS), in part II of this review we embark in a more organ-based description of AGIDS. Adequate space is given to the numerous adverse gastrointestinal effects of nonsteroidal anti-inflammatory drugs. Pill esophagitis, esophagitis dissecans, proton pump inhibitors' effects, diaphragm disease, and the recently described effects of drugs such as olmesartan, mycophenolate, and of compounds such as yttrium-90 are highlighted among several others. The inclusion of drug effects in the differential diagnosis of "conventional" diseases (such as gastric antral vascular ectasia, graft-versus-host disease, ischemic colitis, acute colitis, collagenous enteritis, inflammatory bowel disease) is underscored to avoid sometimes significant diagnostic pitfalls. We reiterate the message of the necessary collaboration between pathologist and clinician in the recognition of these entities to provide the best patient care.

Original languageEnglish (US)
Pages (from-to)202-211
Number of pages10
JournalInternational Journal of Surgical Pathology
Volume22
Issue number3
DOIs
StatePublished - May 2014

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Keywords

  • adverse gastrointestinal tract drug effect
  • diaphragm disease
  • mycophenolate
  • nonsteroidal anti-inflammatory drugs
  • olmesartan

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

De Petris, G., Gatius Caldero, S., Chen, L., Xiao, S. Y., Dhungel, B. M., Wendel Spizcka, A. J., & Lam-Himlin, D. (2014). Histopathological changes in the gastrointestinal tract due to medications: An update for the surgical pathologist (part ii of ii). International Journal of Surgical Pathology, 22(3), 202-211. https://doi.org/10.1177/1066896913502230